The Dog Cancer Survival Guide (133 page)

Modulation of anti-apoptotic and survival pathways by curcumin as a strategy to induce apoptosis in cancer cells. Reuter S, et al.
Biochem Pharmacol
. 2008 Dec 1;76(11):1340-51.

Curcumin-induced antiproliferative and proapoptotic effects in melanoma cells are associated with suppression of IkappaB kinase and nuclear factor kappaB activity and are independent of the B-Raf/mitogen-activated/extracellular signal-regulated protein kinase pathway and the Akt pathway. Siwak DR, et al.
Cancer
. 2005 Aug 15;104(4):879-90.

Curcumin synergistically potentiates the growth-inhibitory and pro-apoptotic effects of celecoxib in osteoarthritis synovial adherent cells. Lev-Ari S, et al.
Rheumatology
(Oxford). 2006 Feb;45(2):171-7.

Celecoxib and curcumin synergistically inhibit the growth of colorectal cancer cells. Lev-Ari S, et al.
Clin Cancer Res
. 2005 Sep 15;11(18):6738-44.

Digestive enzymes as cancer treatments

Bromelain’s activity and potential as an anti-cancer agent: Current evidence and perspectives. Chobotova K, Vernallis AB, Majid FA.
Cancer Lett
. 2010 Apr 28;290(2):148-56. Epub 2009 Aug 22. Review.

Bromelain: biochemistry, pharmacology and medical use. Maurer HR.
Cell Mol Life Sci
. 2001 Aug;58(9):1234-45. Review.

Effects of oral bromelain administration on the impaired immunocytotoxicity of mononuclear cells from mammary tumor patients. Eckert K, et al.
Oncol Rep.
1999 Nov-Dec;6(6):1191-9.

On the pharmacology of bromelain: an update with special regard to animal studies on dose-dependent effects. Lotz-Winter H.
Planta Med.
1990 Jun;56(3):249-53. Review.

Bioavailability of 125I bromelain after oral administration to rats. White RR, et al.
Biopharm Drug Dispos
. 1988 Jul- Aug;9(4):397-403.

In vivo antitumoral activity of stem pineapple (Ananas comosus) bromelain. Báez R, et al.
Planta Med
. 2007 Oct;73(13):1377-83. Epub 2007 Sep 24.

Modulation of murine tumor growth and colonization by bromelaine, an extract of the pineapple plant (Ananas comosum L.). Beuth J, Braun JM.
In Vivo
. 2005 Mar-Apr;19(2):483-5.

Bromelain. Orsini RA; Plastic Surgery Educational Foundation Technology Assessment Committee.
Plast Reconstr Surg
. 2006 Dec;118(7):1640-4. Review.

Bromelain inhibits COX-2 expression by blocking the activation of MAPK regulated NF-kappa B against skin tumorinitiation triggering mitochondrial death pathway. Bhui K, et al.
Cancer Lett
. 2009 Sep 18;282(2):167-76. Epub 2009 Mar 31.

Bromelain reversibly inhibits invasive properties of glioma cells. Tysnes BB, et al.
Neoplasia
. 2001 Nov-Dec;3(6):469-79.

Doctor’s literature reviews, Communication, and Patient Preferences

A focus group study of veterinarians’ and pet owners’ perceptions of veterinarian-client communication in companion animal practice. Coe JB, Adams CL, Bonnett BN.,
J Am Vet Med Assoc
. 2008 Oct 1;233(7):1072-80

Evidence-based approach to the medical literature. Fletcher RH, Fletcher SW.
J Gen Intern Med.
1997 Apr;12 Suppl 2:S5- 14. Review.

Building on existing models from human medical education to develop a communication curriculum in veterinary medicine. Adams CL, Kurtz SM.
J Vet Med Educ
. 2006 Spring;33(1):28-37. Review.

Viewpoint: power and communication: why simulation training ought to be complemented by experiential and humanist learning. Hanna M, Fins JJ.
Acad Med
. 2006 Mar;81(3):265-70.

What veterinary clients really want, too? Milani M.,
Can Vet J.
2008 Oct;49(10):1021-4.

Patient preferences versus physician perceptions of treatment decisions in cancer care. Bruera E, et. al.
J Clin Oncol
. 2001 Jun 1;19(11):2883-5.

Doxycyline

Effect of doxycycline on bone turnover and tumor markers in breast cancer (BC) patients with skeletal metastases. Dhesy- Thind SK, et al.
Journal of Clinical Oncology
, 2005 ASCO Annual Meeting Proceedings. Vol 23, No 16S (June 1 Supplement), 2005: 3198

Doxycycline decreases tumor burden in a bone metastasis model of human breast cancer. Duivenvoorden WC, et al.
Cancer Res
. 2002 Mar 15;62(6):1588-91.

Doxycycline and other tetracyclines in the treatment of bone metastasis. Saikali Z and Singh G.
Anticancer Drugs
. 2003 Nov;14(10):773-8. Review.

Use of tetracycline as an inhibitor of matrix metalloproteinase activity secreted by human bone-metastasizing cancer cells. Duivenvoorden WC, Hirte HW, Singh G.
Invasion Metastasis
. 1997;17(6):312-22.

Does doxycycline work in synergy with cisplatin and oxaliplatin in colorectal cancer? Sagar J, et al.
World J Surg Oncol
. 2009 Jan 6;7:2.

Specificity of inhibition of matrix metalloproteinase activity by doxycycline: relationship to structure of the enzyme. Smith GN Jr, et al.
Arthritis Rheum
. 1999 Jun;42(6): 1140-6.

Doxycycline inhibits neutrophil (PMN)-type matrix metalloproteinases in human adult periodontitis gingiva. Golub LM, et al.
J Clin Periodontol
. 1995 Feb;22(2):100-9.

Effects of tetracyclines on angiogenesis in vitro. Fife RS, et al.
Cancer Lett
. 2000 May 29;153(1-2):75-8.

Doxycycline Induces Expression of P Glycoprotein in MCF- 7 Breast Carcinoma Cells. Mealey, KL, et al.
Antimicrob Agents Chemother
. 2002 March; 46(3): 755–761

Early Cancer Development and Detection

Biomarkers for the Early Detection of Cancer An Inflammatory Concept, Roy, H. K. et al. ,
Arch Intern Med
. 2007;167(17):1822-1824.

Detection of associations between diseases in animal carcinogenicity experiments. Mitchell TJ, Turnbull BW. ,
Biometrics
. 1990 Jun;46(2):359-74.

Multistep tumorigenesis and the microenvironment. Schedin P, Elias A.,
Breast Cancer Res.
2004;6(2):93-101. Epub 2004 Feb 12. Review.

Electromagnetic Fields

Residential exposure to magnetic fields and risk of canine lymphoma. Reif JS, Lower KS, Ogilvie GK.
Am J Epidemiol
. 1995 Feb 15;141(4):352-9.

Childhood cancer in relation to distance from high voltage power lines in England and Wales: a case-control study. Draper G, et al.
BMJ.
2005 Jun 4;330(7503):1290.

Extremely low frequency electric fields and cancer: assessing the evidence. Kheifets L, et al.
Bioelectromagnetics
. 2010 Feb;31(2):89-101. Review.

Aggregating disparate epidemiological evidence: comparing two seminal EMF reviews. O’Carroll MJ, Henshaw DL.
Risk Anal
. 2008 Feb;28(1):225-34.

Emotional Self-Management and Oxygen Mask Exercises

A different perspective to approaching cancer symptoms in children. Woodgate RL, Degner LF, Yanofsky R.,
J Pain Symptom Manage
. 2003 Sep;26(3):800-17.

The emotional harbinger effect: poor context memory for cues that previously predicted something arousing. Mather M and Knight M.,
Emotion.
2008 Dec;8(6):850-60.

Dispositional optimism predicts survival status 1 year after diagnosis in head and neck cancer patients. Allison PJ, et. al.,
J Clin Oncol
. 2003 Feb 1;21(3):543-8.

Gratitude influences sleep through the mechanism of presleep cognitions. Wood AM, Joseph S, Lloyd J, Atkins S.,
J Psychosom Res
. 2009 Jan;66(1):43-8.

Gratitude and subjective well-being in early adolescence: examining gender differences. Froh JJ, Yurkewicz C, Kashdan TB.,
J Adolesc.
2009 Jun;32(3):633-50.

Dispositional anger and risk decision-making, Gambetti E and Giusberti F.
Mind & Society
. 2009 Jun; 8(1): 7-20

Immediate effect of high-frequency yoga breathing on attention, Telles, S. et al.
Indian Journal of Medical Sciences
. 2008; 62 (1): 20-22

Cognitive predictors of vigilance. Matthews G, Davies DR, Holley PJ.,
Hum Factors
. 1993 Mar;35(1):3-24.

Intensive meditation training improves perceptual discrimination and sustained attention. MacLean KA, et al.,
Psychol Sci.
2010 Jun;21(6):829-39.

White Coat Hypertension: Relevance to Clinical and Emergency Medical Services Personnel, Khan TV, et al.,
Med- GenMed
. 2007; 9(1): 52.

Counting blessings versus burdens: an experimental investigation of gratitude and subjective well-being in daily life. Emmons RA and McCullough ME.,
J Pers Soc Psychol.
2003 Feb;84(2):377-89.

The effects of deep breathing training on pain management in the emergency department. Downey LV and Zun LS.,
South Med J.
2009 Jul;102(7):688-92.

Frames, Biases, and Rational Decision Making in the Human Brain, De Martino, B. et al.,
Science.
2006 August 4; 313(5787): 684–687.

Jumping to conclusions and delusion proneness: the impact of emotionally salient stimuli. Warman DM and Martin JM.,
J Nerv Ment Dis
. 2006 Oct;194(10):760-5.

Acute stress modulates risk taking in financial decision making. Porcelli AJ and Delgado MR.,
Psychol Sci
. 2009 Mar;20(3):278-83.

Ethoxyquin

The Antioxidant Ethoxyquin and its analogues: a review. Adrianus J. de Koning.
International Journal of Food Properties
, Volume 55, Issue 2 July 2002, pages 451-461

Ethoxyquin alone induces preneoplastic changes in rat kidney whilst preventing induction of such lesions in liver by aflatoxin B1. Manson MM, Green JA, Driver HE.
Carcinogenesis
. 1987 May;8(5):723-8.

Accumulation and depuration of the synthetic antioxidant ethoxyquin in the muscle of Atlantic salmon (Salmo salar L.). Bohne VJ, Lundebye AK, Hamre K.
Food Chem Toxicol
. 2008 May;46(5):1834-43. Epub 2008 Jan 26.

Petfood Insights: Ethoxyquin Redux. Dzanis D.,
Petfood Industry
, December 2009

Ethoxyquin in fish meal, Spark A.
A. Journal of the American Oil Chemists’ Society.
Volume 59, Number 4 / April, 1982

To see the federal regulations that mandate fishmeal be packed with ethoxyquin when shipped, see Code of Federal Regula-tions, Title 49, Volume 2, Revised as of October 1, 2004, CITE:49CFR173.218.

Food and Cooking Carcinogens

Fluoride in canine diets:
http://www.ewg.org/pets/fluorideindogfood

Formation of N-Nitrosopyrrolidine in a dog’s stomach. Amiysliwny, TS, et al.,
Br. J. Cancer
(1974) 30, 279

Acrylamide: a cooking carcinogen?, Tareke E, et. al.,
Chem Res Toxicol
. 2000 Jun;13(6):517-22.

Analysis of acrylamide, a carcinogen formed in heated foodstuffs. Tareke E, et. al.,
J Agric Food Chem
. 2002 Aug 14;50(17): 4998-5006.

Verification of the findings of acrylamide in heated foods. Ahn JS et. al.
Food Addit Contam
. 2002 Dec;19(12):1116-24.

A review of mechanisms of acrylamide carcinogenicity. Besaratinia A and Pfeifer GP.,
Carcinogenesis
. 2007 Mar;28(3):519-28. Epub 2007 Jan 18. Review.

Acrylamide carcinogenicity. Klaunig JE.,
J Agric Food Chem
. 2008 Aug 13;56(15):5984-8. Epub 2008 Jul 15. Review.

A prospective study of dietary acrylamide intake and the risk of endometrial, ovarian, and breast cancer. Hogervorst JG et. al.,
Cancer Epidemiol Biomarkers Prev
. 2007 Nov;16(11):2304- 13.

Determination of acrylamide in processed foods by LC/MS using column switching. Takatsuki S, et al.,
Shokuhin Eiseigaku Zasshi
. 2003 Apr;44(2):89-95.

Nitrate and human cancer: a review of the evidence. Fraser P, et al.
Int J Epidemiol
. 1980 Mar;9(1):3-11.

Renal carcinogenicity of concurrently administered fish meal and sodium nitrite in F344 rats. Furukawa F, et. al.,
Jpn J Cancer Res
. 2000 Feb;91(2):139-47.

Volatile N-nitrosamine formation after intake of nitrate at the ADI level in combination with an amine-rich diet. Vermeer IT, et. al.,
Environ Health Perspect
. 1998 Aug;106(8):459-63.

Endogenously formed N-nitroso compounds and nitrosating agents in human cancer etiology. Bartsch H, et. al.,
Pharmacogenetics
. 1992 Dec;2(6):272-7. Review.