The Dog Cancer Survival Guide (135 page)

Association between canine malignant lymphoma, living in industrial areas, and use of chemicals by dog owners. Gavazza A, et al.
J Vet Intern Med
. 2001 May-Jun;15(3):190-5.

Homeopathy

Ruta 6 selectively induces cell death in brain cancer cells but proliferation in normal peripheral blood lymphocytes: A novel treatment for human brain cancer. Pathak S, et al.
Int J Oncol
. 2003 Oct;23(4):975-82.

Can homeopathic treatment slow prostate cancer growth? Jonas WB, et al.
Integr Cancer Ther.
2006 Dec;5(4):343-9.

Homeopathy in cancer care. Frenkel M.
Altern Ther Health Med
. 2010 May-Jun;16(3):12-6. Review.

Efficacy of homeopathic therapy in cancer treatment. Milazzo S, Russell N, Ernst E.
Eur J Cancer
. 2006 Feb;42(3):282-9. Epub 2006 Jan 11. Review.

Homeopathic medicines for adverse effects of cancer treatments. Kassab S, et al.
Cochrane Database Syst Rev
. 2009 Apr 15;(2):CD004845. Review.

Hospice Care

Early palliative care for patients with metastatic non-small-cell lung cancer. Temel JS, Greer JA, Muzikansky A, Gallagher ER, Admane S, Jackson VA, Dahlin CM, Blinderman CD, Jacobsen J, Pirl WF, Billings JA, Lynch TJ.
N Engl J Med.
2010 Aug 19;363(8):733-42.

Incredible Canine

Olfactory detection of human bladder cancer by dogs: proof of principle study. Willis CM, et. al.
BMJ
. 2004 Sep 25;329(7468):712.

Diagnostic accuracy of canine scent detection in early- and late-stage lung and breast cancers. McCulloch M, et al.,
Integr Cancer Ther
. 2006 Mar;5(1):30-9.

“Seizure Alert Dogs”,
Orlando Sentinel
, May 6, 1990

How D
ogs Think. Coren, Stanley (2004) First Free Press. Simon and Schuster.

“Dog Sense of Hearing”.seefido.com.
http://www.seefido.com/html/dog_sense_of_hearing.htm
. Retrieved on 200810-22.

“Smell”.nhm.org.6 May 2004.
http://www.nhm.org/exhibitions/dogs/formfunction/smell.html
. Retrieved on 2008-10-22.

Dogs: How to Take Care of Them and Understand Them
. Wegler, M. New York: Barrons Educational Series, 1996.

Indole 3 carbinol

Prevention of chromosomal aberration in mouse bone marrow by indole-3-carbinol. Agrawal RC, Kumar S.
Toxicol Lett
. 1999 Jun 1;106(2-3):137-41.

Protective effects of indole-3-carbinol on cyclophosphamideinduced clastogenecity in mouse bone marrow cells. Shukla Y, Srivastava B, Arora A, Chauhan LK.
Hum Exp Toxicol
. 2004 May;23(5):245-50.

Prevention of cyclophosphamide-induced micronucleus formation in mouse bone marrow by indole-3-carbinol. Agrawal RC, Kumar S.
Food Chem Toxicol
. 1998 Nov;36(11):975-7.

Clinical development plan: indole-3-carbinol. [No authors listed].
J Cell Biochem Suppl
. 1996; 26:127-36.

Krill Oil & Fish Oil

Fish oil and treatment of cancer cachexia. Giacosa A and Rondanelli M.
Genes Nutr.
2008 Apr;3(1):25-8.

Eicosapentaenoic acid in treatment-resistant depression associated with symptom remission, structural brain changes and reduced neuronal phospholipid turnover. Puri BK, et al.
Int J Clin Pract
. 2001 Oct;55(8):560-3.

Omega-3 fatty acids and major depression: A primer for the mental health professional, Logan A. C.
Lipids in Health and Disease
. 2004, 3:25

The importance of the ratio of omega-6/omega-3 essential fatty acids. Simopoulos AP.
Biomed Pharmacother
. 2002 Oct;56(8):365-79.

Dietary omega-3 polyunsaturated fatty acids plus vi tamin E restore immunodeficiency and prolong survival for severely ill patients with generalized malignancy: a randomized control trial. Gogos CA, et al.
Cancer
. 1998 Jan 15;82(2):395-402.

Omega-3 fatty acids in major depressive disorder. A preliminary double-blind, placebo-controlled trial. Su KP, et al.
Eur Neuropsychopharmacol
. 2003 Aug;13(4):267-71. Erratum in: EurNeuropsychopharmacol. 2004 Mar;14(2):173.

Eicosapentaenoic acid in treatment-resistant depression associated with symptom remission, structural brain changes and reduced neuronal phospholipid turnover. Puri BK, et al
. Int J Clin Pract
. 2001 Oct;55(8):560-3.

Depression and cancer: mechanisms and disease progression. Spiegel D and Giese-Davis J.
Biol Psychiatry
. 2003 Aug 1;54(3):269-82. Review.

Depression as a predictor of disease progression and mortality in cancer patients: a meta-analysis. Satin JR, Linden W, Phillips MJ.
Cancer
. 2009 Nov 15;115(22):5349-61.

Psychological depression and 17-year risk of death from cancer. Shekelle RB, et al.
Psychosom Med
. 1981 Apr;43(2):117-25.

Psychological distress and cancer mortality. Hamer M, Chida Y, Molloy GJ.
J Psychosom Res.
2009 Mar;66(3):255-8.

Luteolin

Phosphorylation and stabilization. Shi R, et al.
Mol Cancer Ther
. 2007 Apr;6(4):1338-47.

Anti-proliferative and chemosensitizing effects of luteolin on human gastric cancer AGS cell line. Wu B, et al
. Mol Cell Biochem
(2008) Jun;313(1-2):125-32. Epub 2008 Apr 9.

Luteolin as a glycolysis inhibitor offers superior efficacy and lesser toxicity of doxorubicin in breast cancer cells. Du GJ, et al.
Biochem Biophys Res Commun
. 2008 Aug 1;372(3):497-502

Radiosensitization effect of luteolin on human gastric cancer SGC-7901 cells. Zhang Q, et al.
J Biol Regul Homeost Agents
. 2009 Apr-Jun;23(2):71-8.

Intestinal absorption of luteolin and luteolin 7-O-beta-glucoside in rats and humans. Shimoi K, et al.
FEBS Lett
. 1998 Nov 6;438(3):220-4.

Distribution and biological activities of the flavonoid luteolin. López-Lázaro M.
Mini Rev Med Chem
. 2009 Jan;9(1):31-59. Review.

Absorption and excretion of luteolin and apigenin in rats after oral administration of Chrysanthemum morifolium extract. Chen T, et al.
J Agric Food Chem
. 2007 Jan 24;55(2):273- 7.

Intestinal absorption of luteolin from peanut hull extract is more efficient than that from individual pure luteolin. Zhou P, et al. J Agric Food Chem. 2008 Jan 9;56(1):296-300.

Luteolin as an anti-inflammatory and anti-allergic constituent of Perilla frutescens. Ueda H, Yamazaki C, Yamazaki M.
Biol Pharm Bull
. 2002 Sep;25(9):1197-202.

Luteolin, a flavonoid with potentials for cancer prevention and therapy, Lin Y, et al.
Curr Cancer Drug Targets.
2008 November; 8(7): 634-646.

Luteolin, an emerging anti-cancer flavonoid, poisons eukaryotic DNA topoisomerase I. Chowdhury AR, et al.
Biochem J
. 2002 Sep 1;366(Pt 2):653-61.

Design of new anti-cancer agents based on topoisomerase poisons targeted to specific DNA sequences. Arimondo PB and Hélène C.
Curr Med Chem Anticancer Agents
. 2001 Nov;1(3):219-35. Review.

Luteolin induces apoptosis via death receptor 5 upregulation in human malignant tumor cells. Horinaka M, et al.
Oncogene
. 2005 Nov 3;24(48):7180-9.

Luteolin induces apoptosis in oral squamous cancer cells. Yang SF, et al.
J Dent Res.
2008 Apr;87(4):401-6.

Sensitizing HER2-overexpressing cancer cells to luteolininduced apoptosis through suppressing p21(WAF1/CIP1) expression with rapamycin. Chiang CT, Way TD, Lin JK.
Mol Cancer Ther
. 2007 Jul;6(7):2127-38.

Luteolin and luteolin-7-O-glucoside from dandelion flower suppress iNOS and COX-2 in RAW264.7 cells. Hu C and Kitts DD.
Mol Cell Biochem
. 2004 Oct;265(1-2):107-13.

Luteolin inhibits insulin-like growth factor 1 receptor signaling in prostate cancer cells. Fang J, et al.
Carcinogenesis
. 2007 Mar;28(3):713-23. Epub 2006 Oct 25.

Luteolin suppresses inflammation-associated gene expression by blocking NF-kappaB and AP-1 activation pathway in mouse alveolar macrophages. Chen CY, et al.
Life Sci
. 2007 Nov 30;81(23-24):1602-14.

Luteolin inhibits invasion of prostate cancer PC3 cells through E-cadherin. Zhou Q, et al.
Mol Cancer Ther.
2009 Jun;8(6):1684-91.

Pro-apoptotic effects of the flavonoid luteolin in rat H4IIE cells. Michels G, et al.
Toxicology
. 2005 Jan 31;206(3):337-48.

Lymphoma General References

Lymphoma. Bryan JN, in Henry CJ, Higginbotham ML (ed):
Cancer Management in Small Animal Practice
. Missouri. Saunders Elsevier 2010, p 343-350.

Principles of treatment for canine lymphoma. Ettinger SN.
Clin Tech Small Anim Pract
18:92-97, 2003.

Canine lymphoma and lymphoid leukemias. Vail DM, Young KM, in Withrow SJ, Vail DM (eds):
Withrow & MacEwen’s Small Animal Clinical Oncology
. Missouri, Saunders Elsevier, 2007, pp 699-733.

Lymphoma, Dog (Multicentric). Williams LE, in Cote E (2
^nd
ed),
Clinical Veterinary Advisor: Dogs and Cats
. Missouri, Mosby Elsevier, 2011, p 675-678.

Proteomic identification and profiling of canine lymphoma patients. Ratcliffe L, Mian S, Slater K, et al.
Vet Comp Oncol.
7(2):92-105. 2009

Lymphoma Risks

Association between canine malignant lymphoma, living in industrial areas, and use of chemicals by dog owners. Gavazza A, Presciuttini S, Barale R, et al.
J Vet Intern Med
15:190, 2001.

On the association between canine malignant lymphoma and opportunity for exposure to 2, 4-dichlorophenoxyacetic acid. Hayes HM, Tarone RE, Cantor KP.
Environ Res
70:119, 1995.

Re-analysis of 2,4-D use and the occurrence of canine malignant lymphoma. Kaneene JB, Miller R.
Vet Hum Toxicol
41:164, 1999.

Distinct B-cell and T-cell lymphoproliferative disease prevalence among dog breeds indicates heritable risk. Modiano JF, Breen M, Burnett RC, et al.
Cancer Res
65:5654, 2005

The occurrence of tumors in domestic animals. Preister WA, McKay FW, in Zeigler JL (ed):
National Cancer Institute Monographs,
Bethesda, 1980, U.S. Dept of Health and Human Services.

Canine exposure to herbicide-treated lawns and urinary excretion of 2, 4-dichlorophenoxyacetic acid. Reynolds PM, Reif JS, Ramsdell HS, et al.
Cancer Epidemiol Biomarkers Prev
3:233, 1994.

Lymphoma Diagnostics, Staging, and Prognosis

Radiographic abnormalities in canine multicentric lymphoma: a review of 84 cases. Blackwood L, Sullivan M, Lawson H.
J Small Anim Pract
38:62-9, 1997

Canine lymphoma: immunocytochemical analysis of fine-needle aspiration biopsy. Caniatti M, Roccabianca P, Scanziani E, et al.
Vet Pathol
33:204-12, 1996

Gastrointestinal lymphoma in 20 dogs. A retrospective study. Couto CG, Rutgers HC, Sherding RG, et al.
J Vet Intern Med
3:73-8, 1989

Central nervous system lymphosarcoma in the dog. Couto CG, Cullen J, Pedroia V, et al.
J Am Vet Med Assoc
. 184:809-13, 1984

Updates on the management of canine epitheliotropic cutaneous T-cell lymphoma. de Lorimier LP.
Vet Clin North Am Small Anim Pract
36:213, 2006.

Flow cytometric immunophenotype of canine lymph node aspirates. Gibson D, Aubert I, Woods JP, et al.
J Vet Intern Med
18:710, 2004.

Hematologic and bone marrow cytological abnormalities in 75 dogs with malignant lymphoma. Madewell BR.
J An Anim Hosp Assoc
22:235-240, 1986

Canine cutaneous epitheliotropic lymphoma (mycosis fungoides) is a proliferative disorder of CD8+ T cells. Moore PF, Olivry T, Naydan D.
Am J Pathol
. 144:421-9, 1994

Prevalence of leukemic blood and bone marrow in dogs with multicentric lymphoma. Raskin RE, Krehbiel JD.
J Am Vet Med Assoc
194:1427-9, 1989

Prognostic factors in dogs with lymphoma and associated hypercalcemia. Rosenberg MP, Matus RE, Patnaik AK.
J Vet Intern Med
5:268-71, 1991

Parathyroid hormone (PTH)-related protein, PTH, and 1, 25-dihydroxyvitamin D in dogs with cancer-associated hypercalcemia. Rosol TJ, Nagode LA, Couto CG, et al.
Endocrinology
131:1157-64, 1992