Wallach's Interpretation of Diagnostic Tests: Pathways to Arriving at a Clinical Diagnosis (540 page)

BOOK: Wallach's Interpretation of Diagnostic Tests: Pathways to Arriving at a Clinical Diagnosis
13.99Mb size Format: txt, pdf, ePub
   Serum IgA level is increased in ≤50% of patients.
   Serum complement is normal.
   Serum galactose-deficient IgA1 concentration is frequently elevated.
   Serum levels of glycan-specific IgG antibodies have been found to correlate with urinary protein excretion and risk of progression to ESRD or death.
Suggested Reading

Wyatt RJ, Julian BA. IgA nephropathy.
N Engl J Med.
2013;368(25):2402–2414.

INTERSTITIAL NEPHRITIS
   Definition
   This immune-mediated condition is characterized by the presence of inflammatory infiltrate in the kidney interstitium. The onset can be acute or chronic.
   Drug therapy is responsible for more than 75% of acute interstitial nephritis (AIN) cases. The major causative drugs include antibiotics (e.g., beta lactams, cephalosporins, rifampin), sulfonamide diuretics, and NSAIDs.
   Other causes include
   Infections (5–10% of cases): group A β-hemolytic streptococcal infections, diphtheria, brucellosis, leptospirosis, infectious mononucleosis, toxoplasmosis
   Systemic diseases (10–15% of cases): SLE, Sjögren syndrome, sarcoidosis
   Tubulointerstitial nephritis and uveitis (TINU syndrome)
   Toxic substances
   Who Should Be Suspected?

Other books

Taming the Tycoon by Amy Andrews
Powerstone by Malcolm Archibald
Kilted Lover by Nicole North
The World's End Affair by Robert Hart Davis
Seduction in Session by Shayla Black, Lexi Blake
The Dog Cancer Survival Guide by Demian Dressler, Susan Ettinger
Altar of Eden by James Rollins
Earth Star by Edwards, Janet