Wallach's Interpretation of Diagnostic Tests: Pathways to Arriving at a Clinical Diagnosis (396 page)

   Tricyclic antidepressants: imipramine, amitriptyline

   Phenothiazines: chlorpromazine, trifluoperazine

   Anesthetics: halothane

   Epsilon aminocaproic acid administered in large doses

   Radiographic contrast agents

   Certain foods (onions, garlic, ginger, black tree fungus) and food supplements

   Disease Induced

   Myeloproliferative neoplasms: moderately severe defect.

   Myelodysplastic syndromes usually mild defect.

   Uremia: defect due to accumulation of guanidinosuccinic acid. It is partially corrected by dialysis. Platelet counts are normal.

   Liver disease: normal platelet counts, except in cases with hypersplenism. Dysfunctional platelets may contribute to bleeding risk.

   Dysproteinemias as seen in multiple myeloma and Waldenström macroglobulinemia: normal platelet counts, except in advanced cases, or as the result of chemotherapy.

   DIC affects platelet function mostly due to the effect of fibrin degradation products (FDP) on platelets.