The Lucky Years: How to Thrive in the Brave New World of Health (40 page)

BOOK: The Lucky Years: How to Thrive in the Brave New World of Health
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22
. S. F. Nielsen, B. G. Nordestgaard, and S. E. Bojesen, “Statin Use and Reduced Cancer-Related Mortality,”
New England Journal of Medicine
367, no. 19 (November 8, 2012): 1792–802, doi:10.1056/NEJMoa1201735. Also see S. F. Nielsen, B. G. Nordestgaard, and S. E. Bojesen, “Statin Use and Reduced Cancer-Related Mortality,”
New England Journal of Medicine
368, no. 6 (February 7, 2013): 576–77, doi:10.1056/NEJMc1214827.

23

C. R. Cardwell et al., “Statin Use and Survival from Lung Cancer: A Population-Based Cohort Study,”
Cancer Epidemiology, Biomarkers & Prevention
24, no. 5 (May 2015): 833–41, doi:10.1158/1055-9965.EPI-15-0052.

24
. Leah Lawrence, “Statins Linked with Reduced Liver Cancer in Low-Rate Areas,” Cancer Network, March 19, 2015,
www.cancernetwork.com/gastrointestinal-cancer/statins-linked-reduced-liver-cancer-low-rate-areas#sthash.mYYAMgXP.dpuf
.

25
. L. C. Harshman, “Statin Use at the Time of Initiation of Androgen Deprivation Therapy and Time to Progression in Patients with Hormone-Sensitive Prostate Cancer,”
JAMA Oncology
1, no. 4 (July 1, 2015): 495–504, doi:10.1001/jamaoncol.2015.0829.

26
. C. R. Cardwell et al., “Statin Use After Colorectal Cancer Diagnosis and Survival: A Population-Based Cohort Study,”
Journal of Clinical Oncology
32, no. 28 (October 1, 2014): 3177–83, doi:10.1200/JCO.2013.54.4569, Epub August 4, 2014.

27
. T. J. Murtola et al., “Statin Use and Breast Cancer Survival: A Nationwide Cohort Study from Finland,”
PLOS ONE
9, no. 10 (October 20, 2014): E110231, doi:10.1371/journal.pone.0110231. eCollection 2014.

28
. A. Pursnani et al., “Guideline-Based Statin Eligibility, Coronary Artery Calcification, and Cardiovascular Events,”
Journal of the American Medical Association
314, no. 2 (July 14, 2015): 134–41, doi:10.1001/jama.2015.7515.

29
. J. M. Patel et al., “Randomized Double-Blind Placebo-Controlled Trial of 40 Mg/Day of Atorvastatin in Reducing the Severity of Sepsis in Ward Patients (ASEPSIS Trial),”
Critical Care
16, no. 6 (December 11, 2012): R231, doi:10.1186/cc11895. For an intriguing commentary on this phenomenon, see David S. Fedson and Steven M. Opal, “Can Statins Help Treat Ebola?,”
New York Times
, August 15, 2014.

Chapter 9: The Butterfly Effect

1
. Malcolm Gladwell,
Blink: The Power of Thinking Without Thinking
(New York: Little, Brown, 2005).

2
. Excerpt from Gladwell,
Blink: The Power of Thinking Without Thinking
, iBooks.
https://itun.es/us/wByuv
.

3
. Michael Kimmelman, “ART; Absolutely Real? Absolutely Fake?,”
New York Times
, August 4, 1991.

4
. Charles Duhigg,
The Power of Habit: Why We Do What We Do in Life and Business
(New York: Random House, 2012).

5
. For a comprehensive review of perceptual intuition, see Benedict Carey, “Brain Calisthenics for Abstract Ideas,”
New York Times
, June 6, 2011. Also see Carey, “Learning to See Data,”
New York Times
, March 27, 2015.

6

To learn more about Muhammad Yunus and his work, visit the Yunus Center’s website at
http://muhammadyunus.org
.

7
. To read Lorenz’s original academic paper, go to
http://eaps4.mit.edu/research/Lorenz/Butterfly_1972.pdf
.

8
. J. Lightwood and S. A. Glantz, “The Effect of the California Tobacco Control Program on Smoking Prevalence, Cigarette Consumption, and Healthcare Costs: 1989–2008,”
PLOS ONE
8, no. 2 (2013): E47145, doi:10.1371/journal.pone.0047145, Epub February 13, 2013.

9
. Federal Trade Commission. Federal Trade Commission Cigarette Report for 2012.

10
. “Youth and Tobacco Use,” Centers for Disease Control and Prevention, last modified July 24, 2015,
www.cdc.gov/tobacco/data_statistics/fact_sheets/youth_data/tobacco_use/index.htm
.

11
. Aldous Huxley,
Brave New World
(New York: Random House, 1932), chap. 17.

Index

A note about the index:
The pages referenced in this index refer to the page numbers in the print edition. Clicking on a page number will take you to the ebook location that corresponds to the beginning of that page in the print edition. For a comprehensive list of locations of any word or phrase, use your reading system’s search function.

Page numbers in
italics
refer to illustrations.

acute lymphoblastic leukemia,
115

adenocarcinomas,
216

Advil,
66

“Aequanimitas” (Osler),
75

Affordable Care Act,
69
–70

aflibercept (Zaltrap),
117

Africa,
76
–77,
78
,
163
,
186

age:

biological,
45
–48,
46
,
232

chronological,
45
,
46
,
46
,
47
,
135
–36,
232

aging,
175
,
201

coarse-graining in,
231
–32

context and,
45

diseases of,
41
,
128
,
136

feebleness and,
43

fertility and,
43

genetics and,
20
,
41

immune system and,
44

in males vs. females,
63
–64

mortality rates and,
42
–43

muscle loss in,
195
–96

in other species,
41
–45

parabiosis experiments on,
1
–4,
3
,
21

plasma transfusions and,
4
–5

senility and,
44

telomeres and,
64
–65

theories of,
40
–41

AIDS,
see
HIV/AIDS

airport noise, cardiovascular disease and,
92

Alabama,
47

alcohol abuse,
22

ALK,
51
,
53
–54

Alzheimer’s disease,
5
,
8
,
10
,
91
,
108
,
113
,
118
,
129
,
163
,
175
,
203
–4,
215

diet and,
163

American College of Cardiology,
218

American Heart Association,
183
,
218

American Institute for Cancer Research,
190

American Journal of Clinical Nutrition,
194

amino acids,
194

Amsterdam, University of,
41

amyotrophic lateral scleroris (ALS),
119
–20

Angell, Marcia,
178

Annals of Internal Medicine,
181

Anopheles
mosquito,
77

Antarctica,
94

antiaging drugs,
201

antiaging hoaxes,
200
–201

antibiotics,
145

appendicitis and,
94

resistance to,
67
–69,
68

antibodies,
84
–85

antidepressants,
145

antioxidants,
208

antivaccine movement,
155
–56

anxiety,
122

apoptosis,
59

appendicitis,
93
–94

Apple,
23
,
26

Archives of Internal Medicine,
142
,
143
,
192
,
196

Arizona State University,
134

arthritis,
24
,
215

artificial sweeteners,
85
–86,
120

Asia,
77

aspirin,
76
,
93
,
136
,
215
–17

anticancer qualities of,
216
–17

Associated Press,
21

asthma,
59

Athens,
226

atherosclerosis,
183

ATP (adenosine triphosphate),
107

Auckland, University of,
181

Aurora shooting,
81

Australia,
41
,
124
,
164
,
197
–98

Autier, Philippe,
180
–81

autism spectrum disorders,
108
,
112

vaccines and,
18
,
153
,
155
–56

autoimmune diseases,
85
,
125
,
175

Avastin (bevacizumab),
11

Ayurveda,
113

bacteria:

antibiotic-resistant,
67
–69,
68

beneficial,
33
–34

as earth’s first inhabitants,
124

bacterial genes,
107
,
119

bacterial sepsis,
222

balance,
45

Baltimore, David,
102
,
103

Baltimore, Md.,
74

Bang, Hans Olaf,
182
–83

Bangladesh,
232
–35

Beaverton, Oreg.,
109

Benda, Carl,
107

Berlin,
232
,
233

Bernardi, Edward,
104
–5

Bernardi, Neil,
104
,
105
–6

Bernardi, Sharon,
104
–6,
108
–9,
111

bevacizumab (Avastin),
11

Big Data,
see
databases, medical; data mining

Big Pharma,
see
pharmaceutical industry

Bill & Melinda Gates Foundation,
87

Bills of Mortality,
96
,
97
–99,
98
,
99
,
100

“biological age,”
45
–48,
46
,
232

biomarkers,
45
,
47

biopsies, blood-based,
61

Black Death,
95
–101,
98
,
99
,
100

bladder cancer,
54
–55,
54

blastocysts,
109

Blink: The Power of Thinking Without Thinking
(Gladwell),
225

blood-brain barrier,
54

blood clotting,
187

blood pressure,
22
,
47
,
188
,
195
,
218

home measurement of,
135
,
136

range of,
136

blood sugar levels,
151

body:

as complex organism,
20
,
48
,
135

as emergent system,
48
,
130
–31

listening to,
26
,
150
,
163

resilience of,
49

“self” vs. “nonself” in,
34

body mass index (BMI),
22
,
134
,
141

Boston, Mass.,
84

Boston Cooking-School Cook Book, The,
178

Boston University,
47

Bowerman, Bill,
199

brain:

decision making in,
227

sleep’s importance to,
208
–10

brain cancer,
30

Brave New World
(Huxley), viii,
159
,
238

Brazil,
199

BRCA genes,
8
,
21
,
118

breast cancer,
8
,
53
,
55
,
60
,
61
,
118
,
171
,
190
,
211

genetic mutation and,
21
–22

mastectomies and,
21
–22

obesity and,
133

statin use and,
220

Breast Cancer Prevention Trial,
53

Brigham and Women’s Hospital,
84

Broad Institute of MIT and Harvard,
23
,
24

Broedel, Max,
73

Brown University,
58

Brunet, Anne,
63

bubonic plague,
95
–101

Bulletin of the New York Academy of Medicine,
2

butterfly effect,
236
–37

California,
5
,
12
,
47
,
103

tobacco control program in,
237

California, University of:

at Berkeley,
25

at Irvine,
3

at San Francisco,
3

Caltech,
102

Cambridge, University of,
125
,
134

Cameron, David,
67

Canada,
4
,
11

cancer,
41
,
108
,
128
,
175
,
215
,
237

aggressiveness of,
53
–54

alternative treatments for,
18

aspirin and,
216
–17

chemotherapy for,
29

childhood,
6
,
49
,
170
–71

context and,
13
–14

diet and,
163

early detection and treatment of,
172

fitness and,
190
–94

genetic mutations and,
14
,
21
–22,
50

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