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Authors: T. Colin Campbell,Thomas M. Campbell

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402                                    THE CHINA STUDY
13. Ornish, D., Brown, S. E., Scherwitz, L. W, Billings,]. H., Armstrong, W T., Ports, T. A., McLa-
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Appendix A
1. BoydjN, Misslbeck N, Parker RS, et al. "Sucrose enhanced emergence of aflatoxin B[ (AFB 1) -
i n d u c e d GGt positive rat hepatic cell foci." Fed. Proc. 41 (1982): 356 Abst.
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(1953): 451-501.
3. Youngman LD. The growth and development of aflatoxin Bl-induced preneoplastic lesions, tu-
mors, metastasis, and spontaneous tumors as they are influenced by dietary protein level, type, and
intervention. Ithaca, NY: Cornell University, Ph.D. Thesis, 1990.
4. Youngman LD, and Campbell TC. "Inhibition of aflatoxin Bl-induced gamma-glutamyl
transpeptidase positive (GGT+) hepatic preneoplastic foci and tumors by low protein diets:
evidence that altered GGT+ foci indicate neoplastic potential." Carcinogenesis 13 (1992):
1607-1613.
5. Horio F, Youngman LD, Bell RC, et al. "Thermogenesis, low-protein diets, and decreased de-
v e l o p m e n t of AFBl-induced preneoplastic foci in rat liver." Nutr. Cancer 16 (1991): 31--41.
6. Bell RC, Levitsky DA, and Campbell TC. "Enhanced thermogenesis and reduced growth rates
do not inhibit GGT+ hepatic preneoplastic foci development." FASEB]. 6 (1992): 1395 Abs.
7. Miller DS, and Payne PR. "Weight maintenance and food intake."]' Nutr. 78 (1962): 255-262.
8. Stirling jL, and Stock M]. "Metabolic origins of thermogenesis by diet." Nature 220 (1968):
801--801.
9. Donald P, Pitts GC, and Pohl SL. "Body weight and composition in laboratory rats: effects of
diets with high or low protein concentrations." Science 211 (1981): 185-186.
10. Rothwell Nj, Stock Mj, and Tyzbir RS. "Mechanisms of thermogenesis induced by low pro-
tein diets." Metabolism 32 (1983): 257-261.
11. Rothwell Nj, and Stock M]. "Influence of carbohydrate and fat intake on diet-induced
thermogenesis and brown fat activity in rats fed low protein diets." J Nutr 117 (1987):
1721-1726.
12. Krieger E, Youngman LD, and Campbell TC. "The modulation of aflatoxin(AFB1) induced
preneoplastic lesions by dietary protein and voluntary exercise in Fischer 344 rats." FASEB].
2 (1988): 3304 Abs.
Appendix B
1. Chenj, Campbell TC, Lij, et al. Diet, life-style and mortality in China. A study of the character-
istics of 65 Chinese counties. Oxford, UK; Ithaca, NY; Beijing, PRC: Oxford University Press;
Cornell University Press; People's Medical Publishing House, 1990.
2. There were eight-two mortality rates, but about a third of these rates were duplicates of the
same disease for people of different ages.
403
REFERENCES
3. This also means that very little or no useful information is obtained by including the values of
all the individuals in the county. There is only one disease rate for each county; thus it is only
necessary to have one number for any of the variables being compared with the disease rate.
4. Piazza A. Food consumption and nutritional status in the People~ Republic of China. london:
Westview Press, 1986.
5. Messina M, and Messina V The Dietitian~ Guide to Vegetarian Diets. Issues and Applications.
Gaithersburg, MD: Aspen Publishers, Inc., 1996.
Appendix C
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after graded oral dosing in healthy men." Osteoporosis Int. 8 (1998): 222-230.
3. The biological half-life of storage vitamin D is 10-19 days, the time it takes for half of it to
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4. Colston Kw, Berger U, and Coombes RC. "Possible role for vitamin D in controlling breast
cancer cell proliferation." Lancet 1 (1989): 188-191.
5. Nieves J, Cosman F, Herbert J, et al. "High prevalence of vitamin D deficiency and reduced
bone mass in multiple sclerosis. " Neurology 44 (1994): 1687-1692.
6. Al-Qadreh A, Voskaki I, Kassiou C, et al. "Treatment of osteopenia in children with insulin-
d e p e n d e n t diabetes mellitus: the effect of I-alpha hydroxyvitamin D3." Eur. j. Pediatr. 155
(1996): 15-17.
7. Cantorna MT, Hayes CE, and Deluca HE "1,25-Dihydroxyvitamin D3 reversibly blocks the
progression of relapsing encephalomyelitis, a model of multiple sclerosis. " Proc. National
Acad. Sci 93 (1996): 7861-7864.
8. Rozen F, Yang X-F, Huynh H, et al. "Antiproliferative action of vitamin D-related compounds
and insulin-like growth factor-binding protein 5 accumulation." j. Nat. Cancer Inst. 89
(1997): 652-656.
9. Cosman F, NievesJ, Komar l, et al. "Fracture history and bone loss in patients with MS. "
Neurology 51 (1998): 1161-1165.
10. Giovannucci E, Rimm E, Wolk A, et al. "Calcium and fructose intake in relation to risk of
prostate cancer." Cancer Res. 58 (1998): 442-447.
11 . Peehl DM, Krishnan AV, and Feldman D. "Pathways mediating the growth-inhibitory action
of vitamin D in prostate cancer." j. Nutr. 133(Suppl) (2003): 24615--24695.
12. Zelia JB, McCary lC, and Deluca HE "Oral administration of 1,25-dihydroxyvitamin D3
completely protects NOD mice from insulin-dependent diabetes mellitus. " Arch. Biochem
Biophys. 417 (2003): 77--80.
13. Davenport CB. "Multiple sclerosis from the standpoint of geographic distribution and race."
Arch. Neural. Pschiatry 8 (1922): 51-58.
14. Alter M, Yamoor M, and Harshe M. "Multiple sclerosis and nutrition." Arch. Neurol. 31
(1974): 267-272.
15. Van der Mei lA, Ponsonby AL, Blizzard L, et al. "Regional variation in multiple sclerosis
prevalence in Australia and its association with ambivalent ultraviolet radiaion." Neuroepide-
miology 20 (2001): 168-174.
16. McLeodJG , Hammond SR, and Hallpike JE "Epidemiology of multiple sclerosis in Australia.
With NSW and SA survey results. " Med.j. Austr 160 (1994): 117-122.
17. Holick ME "Vitamin D: a millenium perspective." j. Cell. Biochem. 88 (2003): 296-307.
18. MacLaughlinJA, Gange W, Taylor D, et al. "Cultured psoriatic fibroblasts from involved and
uninvolved sites have a partial, but not absolute resistance to the proliferation-inhibtion ac-
tivity of 1,25-dihydroxyvitamin Ds" Proc. National Acad. Sci 52 (1985): 5409-5412.
404                                 THE CHINA STUDY
19. Goldberg P, Fleming MC, and Picard EH. "Multiple sclerosis: decreased relapse rate through
dietary supplementation with calcium, magnesium and vitamin D." Med. Hypoth. 21 (1986):
193-200.
20. Andjelkovic Z, Vojinovic J, Pejnovic N, et al. "Disease modifying and immunomodulatory
effects of high dose la(OH)D) in rheumatoid arthritis patients." elin. Exp. Rheumatol. 17
(1999): 453-456.
21. Hypponen E, laara E, Reunanen A, et al. "Intake of vitamin D and risk of Type 1 diabetes: a
birth-cohort study." Lancet 358 (2001): 1500-1503.
22. Breslau NA, Brinkley l, Hill KD, et al. "Relationship of animal protein-rich diet to kidney
stone formation and calcium metabolism."]' elin. Endocrinol. Metab. 66 (1988): 140-146.
23. Langman CB. "Calcitriol metabolism during chronic metabolic acidosis." Semin. Nephrol. 9
(1989): 65-71.
24. Chan JM , Giovannucci El, Andersson S-O, et al. "Dairy products, calcium, phosphorus,
vitamin D, and risk of prostate cancer (Sweden)." Cancer Causes and Control 9 (1998):
559-566.
25. Byrne PM, Freaney R, and McKenna MJ. "Vitamin D supplementation in the elderly: review
of safety and effectiveness of different regimes." Calcified Tissue Int. 56 (1995): 518-520.
26. AgranoffBW, and Goldberg D. "Diet and the geographical distribution of multiple sclerosis."
Lancet 2(7888) (November 21974): 1061-1066.
27. Akerblom HK, Vaarala 0, Hyoty H, et al. "Environmental factors in the etiology of Type 1
diabetes." Am.]. Med. Genet. (Semin. Med. Genet.) 115 (2002): 18-29.
28. Chan JM, Stampfer MJ, Ma J, et al. "Insulin-like growth factor-I (IGF-I) and IGF binding
protein-3 as predictors of advanced-stage prostate cancer." J Nat! Cancer Inst 94 (2002):
1099-1109.
29. Cohen P, Peehl DM, and Rosenfeld RG. "The IGFaxis in the prostate." Horm. Metab. res. 26
(1994): 81-84.
30. Doi SQ, Rasaiah S, Tack I, et al. "low-protein diet suppresses serum insulin-like growth fac-
tor-I and decelerates the progresseion of growth hormone-induced glomerulosclerosis." Am.
]. Nephrol. 21 (2001): 331-339.
31. Heaney RP, McCarron DA, Dawson-Hughes B, et al. "Dietary changes favorably affect bond
remodeling in older adults."]' Am. Diet. Assoc. 99 (1999): 1228-1233.
32. Allen NE, Appleby PN, Davey GK, et al. "Hormones and diet: low insulin-like growth factor-I
but normal bioavailable androgens in vegan men." Brit.]. Cancer 83 (2000): 95-97.
Index
American Heart Association, 131
7,12-dimethybenz(a)anthracene
American Institute for Cancer Research
(DBMA),65
(AICR), 261-67
A American Meat Institute, 290
amino acids, 29-30
academia, 311-13
aminotriazole, 44
acrylamide, 235
Anderson, j a m e s , 151 , 154
additives, food, 253
adverse drug reactions, 16, 335 Angell, Marcia, 316-17, 333-34
affluence, diseases of. See diseases of angina, 113
angioplasty, 122, 124
affluence
animal-based diet, 21, 28
aflatoxin, 5,236
antioxidants, 92
binding to DNA, 51-53
blood cholesterol, 77-78, 80-81
children, 36
breast cancer, 85-89, 285
in com, 35-36
calorie consumption, 367
foci development, 54,59
comparison with plant-based
liver cancer, 21, 35-36, 49
diet, 358
low-protein diet, 53
diabetes, 149-50
in peanuts and peanut butter, 35-36
dietary fat, 83, 86
protein, 51-59
government promotion of, 258
tumor development, 60-61
heart disease , 11 7-19
Agriculture, United States Department
historical baSis, 344-45
of,28
hormones (reproductive) , 88, 160,
Alar, 43
160-61
alcohol, 281
alternative medicine, 252, 334 IGF-l (Insulin-like Growth Factor
1), 179
Alzheimer's disease, 218-22
large bowel cancer, 170, 170-71
See also cognitive impairment
nutrition, 230, 230-32
American Cancer Society, 263-64, 267
prostate cancer, 178
American Council on Science and Health
tumor development, 66-67
(ACSH),259-60
American Diabetes Association, 152 in the United States, 274, 276-78
405
406                              THE CHINA STUDY
vitamin D, 179-81 beta-amylOid, 219, 221
See also dairy foods beta-carotene, 93, 94, 229
biomarkers, 21, 88-89, 94, 199
animal-based protein
blood cholesterol, 77, 1 0 6 - 7
biomarkers, 88-89
blood cholesterol, 80, 173 animal-based protein, 80, 173
calcium, 205 breast cancer, 87
cancer, 367 cancer, 78-79
diabetes, 149-55, 152, 154
in China, 274
diet and nutrition, 80-81
dietary fat, 276-78, 278
heart disease, 119 , 120 heart disease, 114-15
IGF-l (Insulin-like Growth Factor liver cancer, 104
1),367 blood sugar. See diabetes
kidney stones, 212-14,213 BMD (bone mineral density), 210
BMI (body mass index) , 100, 135-36,
osteoporosis, 205-8
quality of protein, 30 136
in the United States, 274 body fat, 78
body mass index (BMI), 100, 135-46,136
urinary calcium, 206, 214
vitamin D, 200, 365-67, 366 body size, 102-4
bone mineral density (BMD) , 210
animal experimentation, 45 , 48, 62-64,
bovine serum albumin (BSA), 188
67,351-52
BRCA 1 and 2, 1 5 8 , 1 6 2
animal foods industry, 252, 255-68
See also food industry breast cancer
alcohol, 281
antigens, 185-86
antioxidants, 3, 66, 92-93, 214-17, biomarkers, 21
blood cholesterol, 87
219-20, 3 0 1 - 2
Applebaum, Howard, 258 bone mineral density, 210
casein, 65
apples, 43
in China, 70
Appleton, Scott, 54
arthritis, 199, 210,338 death rates, 275
artificial sweeteners, 44 diet and nutrition, 65, 84-86, 85-89,
ascorbic acid, 93 271-83 , 285
atherosclerosis, 117 dietary fat, 83-89, 84-86, 271-75,275
Atkins Center for Complementary estrogen, 87-88, 160-61, 164
Medicine, 96-97 genetic predispOSition to, 158, 161-62
Atkins Diet. See high-protein diet hormone replacement therapy (HRT),
Atwater, Wilbur 0., 28 166-67
hormones (reproductive), 3, 87-88,
Auburn University, 32
autoimmune diseases, 183-87, 184, 199- 160, 164, 167-68
201,237,349 menarche, 87
See also diabetes; multiple sclerosis risk factors, 160, 160-61
scientific studies, 21, 167-68, 2 7 2 - 8 5
Autret, M., 33
survival rates, 163
B tamoxifen, 163-64
in the United States, 71 , 79
B-cells, 185
See also BRCA 1 and 2
Bauman, Dale, 297-98, 300
Bristol-Myers Squibb Company, 328
Baxter Healthcare Corporation, 328
IN 0EX                                      407
See also carcinogens; diseases of
Brokaw, Tom, 258
BSA (bovine serum albumin), 188 affluence; tumor development;
Burger King, 312 specific types of cancer
Burkitt, Denis, 89-91,170-71 Cancer Atlas Survey, 70-71
Bush, George W, 168, 175-76 carbohydrates, 97-99, 149-55, 174,
306-8
C See also high-protein diet
carcinogens, 43-47, 49, 52
Caedo, Jose, 36
calcitrol, 208 carotenoid antioxidants, 3, 66, 92-93,
214-20, 3 0 1 - 2
calcium
Carroll, Ken, 84, 274-75
animal-based protein, 205
casein
consumption, 209
breast cancer, 65
large bowel cancer, 174-75
osteoporosis, 209 cancer, 6, 59, 65 , 294
vitamin D, 179-81,365-67,366 DNA, 65
Calloway, Doris, 259 foci development, 62
calorie consumption, 99-102,100, 141, HBV (hepatitis B virus), 63-65, 64
367 heart disease, 294
Campbell, Chris, 23,121 tumor development, 60-61
Campbell, T. Colin, xiii-xiv, 4-6, 22, 107, See also dairy foods; high-protein diet;
157, 2 5 3 - 6 8 protein
cancer Castelli, Bill, 79
animal-based protein, 367 cataracts, 217
animal experimentation, 351-52 Cattlemen'S Beef Association, 299, 328
blood cholesterol, 78-79 Cattlemen's Beef Board, 299
body size, 102-3 Chef Combo's Fantastic Adventures, 293
casein, 6, 59, 65, 294 chemicals, environmental, 165-66
in China, 70-71, 71 Chen, Junshi, 67, 69,72, 355
death rates, 13, 70-71, 71 Cheney, Dick, 168
dietary fat, 84, 271 Cheng, Zhiqiang, 63
fiber, 91-92 children
genetic predisposition to, 71, 85, 88-89 aflatoxin poisoning, 36
diabetes, 187-94
geographic distribution, 70
obesity in, 135-37
gluten, 59
likelihood of developing, 12-13 targeted by food industry, 292-95
China
low-protein diet, 53
nutrition, 50, 60-61, 181-82,260-61, breast cancer in, 70
271 calorie consumption, 99-102
plant-based diet, 348-49 cancer in, 70-71,71
protein, 36-37, 51, 65 diet and nutrition, 21-22, 74,273-74,
scientific studies, 53-67, 84, 181-82, 358
HBV (hepatitis B virus), 104
260-61,351-52
liver cancer in, 104
stages of, 48-50, 49
See also China Study; The
tumor development, 61
vitamin C, 93-94 China Study, The, 7, 21-22, 69-108,
vitamins, 269 353-59

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