Wallach's Interpretation of Diagnostic Tests: Pathways to Arriving at a Clinical Diagnosis (987 page)

BOOK: Wallach's Interpretation of Diagnostic Tests: Pathways to Arriving at a Clinical Diagnosis
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HOMOVANILLIC ACID, URINE (HVA)
   Definition
   HVA is the main terminal metabolite of catecholamine neurotransmitter, dopamine. For the diagnosis of neuroblastoma, it is important to carry out simultaneous determinations of HVA and VMA because either or both elevated.
   
Normal range:
0.0–15.0 mg/day.
   Use
   Assist in the diagnosis of pheochromocytoma, neuroblastoma, and ganglioblastoma
   Monitor the course of therapy
   Screening for catecholamine-secreting tumors in children when accompanied by VMA
   Evaluating patients with possible inborn errors of catecholamine metabolism
   Interpretation

Increased In

   Neuroblastoma
   Pheochromocytoma
   Paraganglioma
   Riley-Day syndrome

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