Wallach's Interpretation of Diagnostic Tests: Pathways to Arriving at a Clinical Diagnosis (826 page)

BOOK: Wallach's Interpretation of Diagnostic Tests: Pathways to Arriving at a Clinical Diagnosis
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   Low cross-reactivity with ecgonine methyl ester, norcocaine, ecgonine
   EIA for urine
   Target analyte: benzoylecgonine (metabolite)
   Cutoff concentration:
•   150 ng/mL
•   300 ng/mL
   Approximately 50–60% cross-reactivity with cocaine and cocaethylene
   Low cross-reactivity with EME, ecgonine
   Confirmation assays are commonly chromatography based regardless of the specimen.
   GC/MS
   Full scan mode for qualitative identification of cocaine, cocaethylene, and metabolites: limits of detection—20–50 ng/mL
   Selected ion-monitoring mode for quantitative analysis of serum, plasma for cocaine, cocaethylene, and metabolites: limits of quantitation—5–20 ng/mL
   LC/MSn (multiple MS)
   Multiple reaction–monitoring mode for qualitative or quantitative analysis of cocaine, cocaethylene, and metabolites: limits of detection/ quantitation—20–50 ng/mL
COLD AGGLUTININS
   Definition

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