Wallach's Interpretation of Diagnostic Tests: Pathways to Arriving at a Clinical Diagnosis (784 page)

BOOK: Wallach's Interpretation of Diagnostic Tests: Pathways to Arriving at a Clinical Diagnosis
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   Limitations
   Screening assays are commonly immunoassay based.
   ELISA for blood, serum, plasma
   Target analyte: delta-9-THC
   Cutoff concentration–variable 2–5 ng/mL
   May exhibit significant cross-reactivity with 11-hydroxy-THC, carboxy-THC [THC-COOH]
   Low cross-reactivity with cannabidiol, cannabinol, delta-8-THC
   EIA for urine
   Target analyte: THC-COOH (metabolite)
   Cutoff concentration: 20 ng/mL, 50 ng/mL
   Approximately 50% cross-reactivity with cannabinol, 11-OH-THC
   Confirmation assays are commonly chromatography based regardless of specimen
   Highly glucuronidated–hydrolysis recommended for analysis of urine

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