The Antidote: Inside the World of New Pharma (75 page)

aurora kinases,
107

Aventis,
65
,
68
,
77
–78,
85
,
99
,
215

Avonex,
71
,
91

azidothymidine (AZT),
20
,
24
,
26
,
31
–32,
49
,
148

bacteria,
17
,
34
,
48

CF and,
80
,
119
,
125
–26,
249

Bactrim,
32

bailouts,
187
,
195

Bank of America, Bank of America–Merrill Lynch (BOA-ML),
186
,
329
,
332
,
340
,
344

Barber, Zach,
370

Barrons.com,
368
–69

Beall, Robert,
67
–69,
79
–80,
111
,
125
,
141
–42,
181
–82,
297
,
345
,
361

Bear Stearns,
178
–79,
186

Belgium,
113
–14,
130
,
136
,
208
,
223

Berdella, Maria,
303

Berlin:

AIDS conference in,
19
–20,
30
,
36
,
76

EASL meeting in,
258
,
262

Sanford C. Bernstein & Co.,
96
–97,
101
,
194
,
250
,
298
,
315
,
368

Beth Israel Medical Center,
253
,
303
,
305
,
307

“Big and Dangerous Day for Personalized Medicine, A” (Herper),
251

Big Hairy Audacious Goal (BHAG),
116
,
158
–60,
162

Big Pharma,
20
,
40
,
46
,
63
,
65
,
77
,
80
,
86
,
108
,
123
,
216
,
244
,
331
,
380
,
385

bilirubin,
270
–73

Billion-Dollar Molecule, The
(Werth),
2
,
142
,
386

Bill of Rights,
365
–66

BILN-2061,
82
,
105
–6,
129
–31

Biogen,
41
,
71

biologics,
12
,
39
,
71
,
78
,
91
,
177
,
193
,
195
,
202
–3,
217
,
250

biotechnology, biotechnology companies,
2
,
12
,
27
,
51
–52,
86
,
96
,
110
–11,
140
,
144
,
179
,
189
,
208
,
261
,
287
,
311
,
342

bubble of,
65
,
77
,
87
,
145
–46,
192

China and,
174

finances of,
43
,
59
,
101
–2,
177
–78,
192

German academic model,
108

hedge funds and,
199

mergers and acquisitions in,
84
,
331

Morgan conference and,
76
,
192
–93,
216

profitability of,
4
–5

stock market declines and,
313

turnover of employees in,
184

Biotechnology Industry Organization (BIO),
153
,
163
,
217

Boger’s chairmanship of,
156
–57,
192
–93

Boger’s speech for,
202
–3

Birnkrant, Debra,
276

black box warnings,
208
,
378

blood, bloodstream,
24

disorders of,
56
,
75

EPO and,
192
,
208

HCV and,
21
,
42
,
47
,
62
–63,
94
–95,
112
–14,
148
,
165
,
203
,
213
,
221
–22,
273

HIV and,
25
,
32

blood-brain barrier:

epilepsy and,
215
–16

p38 and,
71
–73,
93

blood thinners,
245

Bloomberg, Michael,
328

Bloomberg News,
380

boceprevir,
see
Victrelis

Boehner, John,
220

Boehringer Ingelheim,
82
–83,
91
,
93
–95,
101
,
105
,
129
,
131
,
150
–51,
172

Boger, Amy,
153
,
322
,
365

Boger, Jack,
279

Boger, Joshua,
1
–7,
11
–16,
106
–11,
114
,
177
,
182
–86,
222
,
225
–26,
230
,
264
,
287
,
314
,
343
,
365
–67,
370
,
376

Alam’s relationship with,
71
,
163
,
183

Aldrich’s relationship with,
60
,
69

ambitions of,
50
,
73
,
97
,
110
,
132
,
152
–53,
242
,
278
–79,
293
,
316

background of,
3
–5,
7
,
12
,
15
,
91
,
94
,
132
,
134
,
152
,
184
,
366
,
381

BIO chairmanship of,
156
–57,
192
–93

blogging of,
153
–56,
174

CF and,
69
–70,
80
,
127
,
143
,
365

charisma of,
12
,
45
,
189
,
294

China and,
172
–74

comparisons between Emmens and,
214
,
216
–17,
237
,
288
,
318

comparisons between Murcko and,
28
–29

earnings calls and,
175
,
178

Emmens on,
184
–85,
189
,
259
,
293
,
316
,
321

expansion strategy of,
84
–87

externalities of,
153
–57

FDA funding and,
202

on future,
387
–89

Garrison hired by,
117
,
122
,
135
,
204

genomics and,
43
,
55
–57,
59
,
65
,
85

goals and,
2
–3,
7
,
43
,
45
,
56
,
65
,
85
–86,
92
,
172
,
178

Hartmann hired by,
123
–24

HCV and,
32
,
34
,
37
–38,
48
,
61
–62,
64
,
75
–77,
83
,
93
–95,
100
,
108
–11,
129
,
132
,
136
–40,
147
,
149
,
153
,
161
,
163
,
165
–67,
173
–74,
182
–83,
193
–94,
373
–75

HIV and,
5
,
18
–20,
24
–27,
30
–32,
35
–36,
46
,
49
–51,
64
,
85
,
91
,
163
–64,
193

Huckman’s interview with,
193
–94,
216

ICE and,
49
,
85

Incivek and,
76
,
109
–11,
131
,
136
,
165
,
178
,
185
,
189
,
194
,
200
,
232
,
239
,
242
,
244
,
293
–94,
316
,
375

on innovation-exclusivity balance,
202
–3

kinases and,
55
–57,
72
–75,
375

launching Vertex and,
1
,
5
,
7

lawsuit against,
75
–76,
128

management style and skills of,
2
,
18
,
27
–28,
34
,
41
,
44
–45,
47
,
65
,
144
,
161
–63,
184
–85,
198
,
206

Milestone Day and,
322
–23

Morgan conference and,
76
–77,
87
,
136
,
192
–93

Murcko’s relationship with,
28
,
145

philanthropy of,
365

physical appearance of,
12
,
28
,
73
–74,
322
–23

portfolio process and,
90
–95,
97
–101

Red Sox and,
69
,
96

relations between board and,
115
–16,
123
–24,
137
–38,
143
,
162
–64,
188
–90,
193
,
197
,
259
,
358

retirement of,
191
,
195
–98,
200
,
203
–6,
211
,
259
,
293
,
321

Sachdev’s hiring and,
163
–64

Smith’s relationship with,
86
–87,
163
,
280
–81,
325

social experiment of,
27
–28,
41
,
65
,
90
,
135
,
150
,
205

speeches of,
11
–13,
75
–77,
85
,
136
,
173
,
193
,
202
–4,
293
–94,
322
–23,
366

succession and,
122
–23,
143
–44,
146
,
164
,
188
–90,
196
,
198
,
358
,
361

values and,
45
,
124
,
133
–34,
153
,
202
–5,
226
,
325
,
358
,
387
–88

Vertex-Kissei partnership and,
12
–13

Vertex-Novartis partnership and,
56
–59,
72
,
107

and Vertex’s acquisition of Aurora,
66
–69,
84
–85

Vertex’s compensation system and,
158

Vertex’s creativity and,
57
,
70
,
161
–62,
387

Vertex’s financial problems and,
87
,
98
,
186

Vertex’s investor day and,
101
–2

and Vertex’s public image and relations,
49
,
243

Vertex’s reorganization and,
59
–60,
64
–65

Vertex Vision Process and,
117
,
133
–34,
158
,
387

Vertex-Wellcome partnership and,
25
–27

VIP teams and,
133
,
157
,
159

vision of,
2
,
6
–7,
60
,
100
,
123
,
153
,
201
,
237
,
247
,
259
,
291
,
316
,
325
,
335
,
374
–75,
386
–87

on Wall Street,
311
–12

Washington retroviral conference and,
25
–26

zero-gravity flight of,
155
–56

Boger, Ken,
35
,
87
,
114
–15,
149
,
163
,
184
–86,
211
–12,
222
,
262
,
275
,
277
–82,
367

background of,
73
–74,
278

CF and,
141
,
248
,
295
–98,
303
–7

earnings calls and,
308
–9

HCV and,
101
,
130
,
244
,
264
,
277
–78

retirement of,
277
,
321

speeches of,
278
–80

Vertex-Novartis partnership and,
106
–7

on Vertex’s reputation,
279
–80

and Werth’s access to Vertex,
386

Boger Tax Plan,
367

Boston
,
153

Boston, Mass.:

Vertex’s partnership with,
370

World Trade Center biotech meeting in,
11
–15,
18
,
85

Boston Convention and Exhibition Center,
320
–24

Boston Cyclorama,
51