Safe Food: The Politics of Food Safety (59 page)

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Authors: Marion Nestle

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12
. Bokanga M. Biotechnology and cassava processing in Africa.
Food Technology
1995;49:86–90. Knorr D. Improving food biotechnology resources and strategies in developing countries.
Food Technology
1995;49:91–93. Messer E. Sources of institutional funding for agrobiotechnology for developing countries.
Advanced Technology Assessment Systems
1992;9:371–378.

13
. Beachy R. Transferring genes. In: Burke WS, ed.
Symbol, substance, science: the societal issues of food biotechnology
(proceedings of a conference, July 28–29, 1993). Research Triangle Park, NC: USDA Office of Agricultural Biotechnology and North Carolina Biotechnology Center, 1993:45–51,61. Beachy RN. Facing fear of biotechnology.
Science
1999;285:335. Dr. Beachy is now president of the Donald Danforth Plant Science Center in St. Louis, MO. Although the center is listed on the Monsanto Web site as a partner, Dr. Beachy says he has not been funded by Monsanto since 1991 (see letters to the editor:
Science
1999;285:1489).

14
. Sommer A, West KP.
Vitamin A Deficiency: Health, Survival, and Vision
. New York: Oxford University Press, 1996. Sommer A.
Vitamin A Deficiency and Its Consequences: A Field Guide to Detection and Control
. 3rd ed. Geneva: World Health Organization, 1995.

15
. Yoon CK. Stalked by deadly virus, papaya lives to breed again.
NYT
, July 20, 1999:F3.

16
. Hamilton JO. Biotech: an industry crowded with players faces an ugly reckoning.
Business Week
, September 26, 1994:84–92.

17
. Wambugu F. Biotechnology: protesters don’t grasp Africa’s need.
Los Angeles Times
, November 11, 2001:M1. Wambugu FM.
Modifying Africa: How Biotechnology Can Benefit the Poor and Hungry, A Case Study from Kenya
, Nairobi, 2001.

18
. Monsanto. Meeting the World’s Needs with Fewer Resources (press release). St. Louis, MO, 1996. Council for Biotechnology Information. Biotechnology and the Developing World (leaflet). The council’s public relations materials appear online at
www.whybiotech.com
.

19
. Ye X, Al-Babili S, Klöti A, et al. Engineering the provitamin A (β-carotene)
biosynthetic pathway into (carotenoid-free) rice endosperm.
Science
2000;287: 303–305. Heldt H-W.
Plant Biochemistry and Molecular Biology
. Oxford: Oxford University Press, 1997.

20
. Dary O, Mora JO. Food fortification to reduce vitamin A deficiency: International Vitamin A Consultative Group recommendations.
J Nutrition
2002; 132:2927S–2933S.

21
. Normile D. Rockefeller to end network after 15 years of success.
Science
1999;286:1468–1469. Christensen J. Golden Rice in a grenade-proof greenhouse.
NYT
, November 21, 2000:F1,F5. Normile D. Monsanto donates its share of Golden Rice.
Science
2000;289:843-845. The scientists describe the patent and legal issues in: Beyer P, Al-Babili S, Ye S, et al. Golden Rice: introducing the β-carotene biosynthesis pathway into rice endosperm by genetic engineering to defeat vitamin A deficiency.
J Nutrition
2002;132:506S–510S.

22
. Nash JM. Grains of hope.
Time
, July 31, 2000:39–46.

23
. Potrykus I. Nutritionally enhanced rice to compete [
sic
] malnutrition disorders of the poor (handout). From Agricultural Biotechnology: The Road to Improved Nutrition and Increased Production? (conference), Boston, Tufts University School of Nutrition Science and Policy, November 2, 2001.

24
. Potrykus I. Golden Rice and beyond.
Plant Physiology
2001;125:1157–1161.

25
. Greenpeace. Background information: the false promise of genetically engineered rice, February 2001. Haerlin B. GE rice is fool’s gold, February 9, 2001. Khoo M. Greenpeace demands false biotech advertising be removed from TV, February 9, 2001, at
www.greenpeace.org/usa
.

26
. The Potrykus group said the rice contained 1.6 micrograms (µg) beta-carotene per gram (g), but thought 2 µg/g realistic. The U.S. standard for vitamin A is 300 µg per day for children aged one to three years, 700 µg for adult women, and 900 µg for adult men. At a conversion rate of 12 µg beta-carotene to 1 µg vitamin A, the beta-carotene standard is 3,600 (12 × 300) µg for young children; 8,400 (12 × 700) µg for women; and 10,800 (12 × 900) µg for men. If Golden Rice contains 2 µg per g beta-carotene, the amounts are halved. Children would need to eat 1,800 g rice (4 lb); women 4,200 g (9 lb); and men 5,400 g (12 lb) a day to meet the U.S. standard for vitamin A. Rice is cooked in twice its volume of added water (example: 1 cup raw rice plus 2 cups water to yield 3 cups cooked rice). Therefore, the amounts of
cooked
rice are 12, 27, and 36 lb per day, respectively. Lower conversion ratios reduce these amounts.

27
. Institute of Medicine.
Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc
. Washington, DC: National Academy Press, 2001:65–126.

28
. Potrykus I. “Genetically engineered ‘Golden Rice’ is fool’s gold”: response from Prof. Ingo Potrykus. Ag BioTech InfoNet, February 10, 1001. Online:
www.biotech-info.net/IP_response.html
.

29
. Conway G. Grain of hope.
Guardian
(London), March 21, 2001. Online:
www.guardian.co.uk
.

30
. Olson JA. Carotenoids. In: Shils ME, Olson JA, Shike M, et al., eds.
Modern Nutrition in Health and Disease
, 9th ed. Philadelphia: Lippincott Williams
& Wilkins, 1998:525–541. Also: Torun B, Chew F.
Protein-Energy Malnutrition
(1998:963–988).

31
. Nestle M. Genetically engineered “golden” rice unlikely to overcome vitamin A deficiency (letter).
J Am Dietetic Association
2001;101:289–290. This letter points out that beta-carotene itself raises questions. Food sources of beta-carotene protect against cancer and heart disease, but supplements do not and may be harmful or beneficial depending on circumstances. The health effects of adding this single nutrient to rice endosperm are uncertain.

32
. Filteau SM, Tomkins AM. Promoting vitamin A status in low-income countries.
Lancet
1999;353;1458–1460. Summer A, Davidson FR, Ramakrishnan U, et al. Twenty-five years of progress in controlling vitamin A deficiency: looking to the future. Proceedings of the XX International Vitamin A Consultative Group Meeting, Hanoi, Vietnam, February 12–15, 2001.
J Nutrition
2002;132(9 suppl):2843S–2990S.

33
. Potrykus I. Golden Rice and the Greenpeace dilemma. Ag BioTech InfoNet, February 15, 2001. Online:
www.biotech-info.net/2_IP_response.html
.

CHAPTER 6. RISKS AND BENEFITS: WHO DECIDES?

1
. Pew Initiative on Food and Biotechnology.
Public Sentiment about Genetically Modified Food
, June 21–23, 2001, at
www.pewtrusts.org/news_room_detail.aspx?id=32822
. The survey included 1,231 adults.

2
. International Food Information Council.
U.S. Consumer Attitudes toward Food Biotechnology
, November 2001. Wirthlin Group Quorum conducted five surveys from 1997 to 2001; Cogent Research conducted the September 2001 telephone survey of about 1,000 adults.

3
. OTA.
New Developments in Biotechnology: Public Perceptions of Biotechnology
(OTA-BP-BA-45), 1987. Also see: Zimmerman L, Kendall P, Stone M, et al. Consumer knowledge and concern about biotechnology and food safety.
Food Technology
1994;48:71–77. Wie SH, Strohbehn CH, Hsu CHC. Iowa dietitians’ attitudes toward and knowledge of genetically engineered and irradiated foods.
J Am Dietetic Association
1998;98:1331–1333.
Genetically Modified Foods: Are You Afraid of Eating Them?
(Poll, December 1999).

4
. Hoban TJ. Consumer acceptance of biotechnology: an international perspective.
Nature Biotechnology
1997;15:232–234. Aerni P. Public attitudes towards agricultural biotechnology in developing countries: a comparison between Mexico and the Philippines. Cambridge, MA: Center for International Development, Harvard University, October 1, 2001, at
www.inai.org.ar/ogm/Public%20Attitudes%20towards%20Agricultural%20Biotechnology%20in%20developing%20countires.pdf
.

5
. Barling D, de Vriend H, Cornelese JA, et al. The social aspects of food biotechnology: a European view.
Environmental Toxicology and Pharmacology
1999;7:85–93. Frewer L. Public perceptions of genetically modified foods in Europe.
J Commercial Biotechnology
1999;6:108–115. Thompson PB.
Food Biotechnology in Ethical Perspective
. London: Blackie Academic & Professional, 1997.

6
. HRH, the Prince of Wales. Seeds of disaster.
Daily Telegraph
(London), June 8, 1998. Reprinted in
Ecologist
1998;28(5):252–253.

7
. Smith G, Gruner P. “Scaremonger” but Charles is right to call for debate.
Evening Standard
(London), June 8, 1998:4.

8
. Thavis J. Vatican experts OK plant, animal genetic engineering.
St. Louis Review
, October 22, 1999:E1. Lyman E. Pope expresses opposition to GMOs: cites need for “the respect of nature.” Bureau of National Affairs, No. 221, November 15, 2000, at
http://online.sfsu.edu/~rone/GEessays/PopeGMO.htm
.

9
. Genetically modified food: food for thought.
Economist
, June 19, 1999: 19–21.

10
. Frederickson DS.
The Recombinant DNA Controversy: A Memoir: Science, Politics, and the Public Interest 1974–1981
. Washington, DC: American Society for Microbiology, 2001. For another view, see: Krimsky S.
Genetic Alchemy: The Social History of the Recombinant DNA Controversy
. Cambridge, MA: MIT Press, 1994.

11
. Commoner B. Unraveling the DNA myth: the spurious foundation of genetic engineering.
Harper’s
, February 2002:39–47.

12
. Fuchs RL, Astwood JD. Allergenicity assessment of foods derived from genetically modified plants.
Food Technology
1996;50(2):83–88. Metcalfe DD, Fuchs RL, Townsend R, et al., eds. Allergenicity of foods produced by genetic modification.
Critical Reviews in Food Science and Nutrition
1996;36(suppl): S1–S186.

13
. Consumer & Biotechnology Foundation.
Genetically Modified Foods and Allergenicity: Safety Aspects and Consumer Information
(workshop proceedings), May 28–29, 1999. Den Haag.
The Netherlands: Stichting Consument en Biotechnologie
, 1999.

14
. Buchanan BB. Genetic engineering and the allergy issue.
Plant Physiology
2001;126:5–7.

15
. Burks AW, Fuchs RL. Assessment of the endogenous allergens in glyphosate-tolerant and commercial soybean varieties.
J Allergy and Clinical Immunology
1995;96:1008–1110.

16
. Winslow R. Allergen is inadvertently transferred to soybean in bioengineering test.
WSJ
, March 14, 1996:B6.

17
. Nordlee JA, Taylor SL, Townsend JA, et al. Identification of a Brazil-nut allergen in transgenic soybeans.
NEJM
1996;334:688–692.

18
. FDA. Statement of policy: foods derived from new plant varieties.
FR
57:22984–22986, May 29, 1992.

19
. FDA. Food labeling: food derived from new plant varieties.
FR
58:25837–25841, April 28, 1993. BIO favors limited notification on biotech food 3-year sunset.
FCN
, May 16, 1994:7–8.

20
. EPA.
FIFRA Scientific Advisory Panel Meeting, November 28, 2000
(SAP Report No. 2000-06), December 1, 2000. EPA Scientific Advisory Panel (SAP) reports are online at:
www.epa.gov/scipoly/sap
[Note: search by date].

21
. Nestor EW, Roberts CE, Pearsall NN, et al.
Microbiology: A Human Perspective
. 2nd ed. Boston: WCB/McGraw-Hill, 1998.

22
. Holmberg SD, Osterholm MT, Senger KA, et al. Drug-resistant
Salmonella
from animals fed antimicrobials.
NEJM
1984;311:617–622. Tacket CO,
Dominguez LB, Fisher HJ, et al. An outbreak of multiple-drug-resistant
Salmonella
enteritis from raw milk.
JAMA
1985;253:2058–2060. White DG, Zhao S, Sudler R, et al. The isolation of antibiotic-resistant
Salmonella
from retail ground meats.
NEJM
2001;345:1147–1154.

23
. FDA. Secondary direct food additives permitted in food for human consumption; food additives permitted in feed and drinking water of animals; amino-glycoside 3’-phosphotransferase II: final rule.
FR
59:26700–26711, May 23, 1994. The kanamycin (neomycin) resistance gene specifies the enzyme, aminoglycoside 3’-phosphotransferase II.

24
. FDA. Guidance for industry: use of antibiotic-resistance marker genes in transgenic plants: draft guidance. September 4, 1998. FDA documents on antibiotic resistance are available at
http://vm.cfsan.fda.gov/~dms/opa-armg.html
.

25
. FDA Task Force on Antimicrobial Resistance.
Key Recommendations and Report
. FDA, December 2000. FDA. HHS releases action plan to combat antimicrobial resistance (press release). January 18, 2001.

26
. Goldburg R, Rissler J, Shand H, et al.
Biotechnology’s Bitter Harvest: Herbicide-Tolerant Crops and the Threat to Sustainable Agriculture
. Washington, DC: Biotechnology Working Group, 1990. Rissler J, Mellon M.
The Ecological Risks of Engineered Crops
. Cambridge, MA: MIT Press, 1996.

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