RISK FACTORS
Adnexal torsion:
- Reproductive-age women
- Ovarian cysts, especially >5 cm
- Ovarian hyperstimulation
- Tumors: Serous cystadenoma most common; teratomas
- Pelvic surgery: Tubal ligation; hysterectomy
- Pregnancy
- History of pelvic inflammatory disease
Pregnancy Considerations
Torsion in pregnancy usually occurs in the 1st trimester, and in vitro fertilization or ovarian induction are risk factors.
Pediatric Considerations
15% of adnexal torsions occur in children
ALERT
- Anticoagulated patients at increased risk of:
- Hemorrhagic corpus luteal cyst
- Significant bleed from ruptured cyst, including with ovulation
ETIOLOGY
- Ovarian cyst:
- Follicular cysts result from nonrupture of mature follicle or failure of atresia of immature follicle
- Corpus luteal cysts result from unrestrained growth in early pregnancy or from normal intracystic hemorrhage days after ovulation
- Other cysts:
- Theca lutein
- Cystic teratoma
- Endometrioma (chocolate cyst)
- Adnexal torsion:
- Right > left
- Highest frequency in reproductive women
ALERT
Cysts found in postmenopausal women suggest carcinoma
DIAGNOSIS
SIGNS AND SYMPTOMS
History
- Ovarian cyst:
- Abdominal pain
- Sharp, unilateral
- Intermittent vs. constant
- Migration
- Previous episodes
- May occur with exercise, intercourse, trauma, or pelvic exam
- Fever is rare
- Irregular menses (may suggest polycystic ovary syndrome)
- Infertility
- Pregnancy status
- Previous STDs
- History of breast or GI cancer (may metastasize)
- Adnexal torsion:
- Variable history
- Abdominal pain:
- Sudden, sharp, colicky
- Localized vs. diffuse
- Referred pain to groin or flank
- May be chronic or recurring with torsion/detorsion
- Fever
- Nausea/vomiting
- Vaginal bleeding
- UTI symptoms
Physical-Exam
- Ovarian cyst:
- Abdominal tenderness (mild to severe with peritonitis)
- Adnexal tenderness
- Pelvic mass
- Hemorrhagic shock possible:
- Usually from corpus luteal cyst rupture
- Orthostasis, hypotension, tachycardia
- Adnexal torsion:
- Abdominal tenderness (mild to severe)
- Adnexal tenderness
- Adnexal mass
ESSENTIAL WORKUP
- Pregnancy test essential to rule out ectopic pregnancy
- Rapid hemoglobin or hematocrit
DIAGNOSIS TESTS & NTERPRETATION
Lab
- Urine or serum human chorionic gonadotropin determination
- CBC
- Urinalysis
- If significant hemorrhage, type and cross packed RBCs
- Cervical cultures to rule out PID
Imaging
- Transvaginal US:
- Adnexal cysts and masses:
- Cystic masses <5 cm in premenopausal women generally benign
- Should be re-evaluated at the end of menstruation
- Pelvic free fluid
- Enlarged, edematous ovary (suggests torsion)
- Doppler:
- May show decreased flow with torsion
- Important to document normal blood flow on Doppler in ED, even though does not rule out recent torsion of ovary
- MRI:
- Consider in pregnant patients with right lower quadrant pain and nondiagnostic US and Doppler
- CT:
- May demonstrate cysts or evidence of torsion or suggest alternative diagnosis
- May provide enough information to proceed to laparoscopy if abnormal ovary and no other cause of pain identified
- Uterus may be shifted to side of torsed adnexa
- Ascites may be present
ALERT
US sensitivity for diagnosis of ovarian torsion is not well established; continue workup if high clinical suspicion
Diagnostic Procedures/Surgery
- Culdocentesis:
- No longer commonly done
- May yield serosanguinous fluid with ruptured cyst
- Hematocrit >15% suggests significant hemoperitoneum
- Laparoscopy is gold standard for torsed adnexa and definitive diagnosis
Pediatric Considerations
- Early detorsion of adnexa by laparoscopy is now advocated to preserve ovarian function
- Followed by frequent follow-up visits to monitor for malignancy
DIFFERENTIAL DIAGNOSIS
- Ectopic pregnancy
- PID
- Round ligament pain
- Endometriosis
- Neoplasm
- Torsion of uterus
- Appendicitis
FOLLOW-UP RECOMMENDATIONS
Ovarian cyst
- If pain is resolved and cyst is <4–5 cm, close follow-up is recommended with gynecology for further studies
PEARLS AND PITFALLS
Adnexal torsion:
- Torsion is a clinical diagnosis:
- US may show flow to an ovary that has detorsed
- Symptoms can be varied and nonspecific
- Always include adnexal torsion in differential of abdominal pain
ADDITIONAL READING
- Becker JH, de Graaff J, Vos CM. Torsion of the ovary: A known but frequently missed diagnosis.
Eur J Emerg Med
. 2009;16:124–126.
- Bottomley C, Bourne T. Diagnosis and management of ovarian cyst accidents.
Best Pract Res Clin Obstet Gynaecol
. 2009;23:711–724.
- Chang HC, Bhatt S, Dogra VS. Pearls and pitfalls in diagnosis of ovarian torsion.
Radiographics.
2008;28:1355–1368.
- Houry D, Abbott JT. Ovarian torsion: A fifteen-year review.
Ann Emerg Med
. 2001;38:156–159.
- McWilliams GD, Hill MJ, Dietrich CS 3rd. Gynecologic emergencies.
Surg Clin North Am
. 2008;88:265–283.
- Moore C, Meyers AB, Capostato J, et al. Prevalence of abnormal CT findings in patients with proven ovarian torsion and a proposed triage schema.
Emerg Radiol
. 2009;16:115–120.
- Oltmann SC, Fischer A, Barber R, et al. Pediatric ovarian malignancy presenting as ovarian torsion: Incidence and relevance.
J Pediatr Surg
. 2010;45:135–139.
- Smorgick N, Pansky M, Feingold M, et al. The clinical characteristics and sonographic findings of maternal ovarian torsion in pregnancy.
Fertil Steril
. 2009;92:1983–1987.
See Also (Topic, Algorithm, Electronic Media Element)
- Abdominal Pain
- Ectopic Pregnancy
- Endometriosis
- Pelvic Inflammatory Disease
CODES
ICD9
- 620.0 Follicular cyst of ovary
- 620.2 Other and unspecified ovarian cyst
- 620.5 Torsion of ovary, ovarian pedicle, or fallopian tube
ICD10
- N83.0 Follicular cyst of ovary
- N83.20 Unspecified ovarian cysts
- N83.51 Torsion of ovary and ovarian pedicle
PAGET DISEASE
Anna L. Waterbrook
•
Matthew C. Kostura
BASICS
DESCRIPTION
- Paget disease involves resorption of normal bone and its replacement with fibrous and sclerotic tissue
- Also known as osteitis deformans
- Usually focal, bones most frequently involved include:
- Pelvis (70%)
- Femur (55%)
- Skull (42%)
- Tibia (32%)
- Spine (53%, lumbar spine)
- Flat bones
- Usually found incidentally and generally asymptomatic
- Occurs in ∼1–2% of patients >55 yr old
- Incidence increases with age
- Starts with resorptive or osteolytic phase, during which osteoclasts remove healthy bone
- Hypervascularity begins in resorptive phase:
- Predisposes to hematoma and fracture
- Resorbed bone is eventually replaced by irregular, dense, disorganized trabecular bone in sclerotic or osteoplastic phase forming “mosaic pattern”
- Malignant transformation is rare:
- Osteosarcoma is malignancy of concern
- Usually malignant transformation occurs in 1%
- More common in men
- More common in European descent
- Less common in Asian or Scandinavian descent
- Typically involves 1 bone (monostotic)
- May involve a few bones (polyostotic)