Power, Sex, Suicide: Mitochondria and the Meaning of Life (64 page)

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Authors: Nick Lane

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—— Lapeña, A. C., Díez-Sánchez, C., Pérez-Martos, A., Montoya, J., Alvarez, E., Díaz, M., Urriés, A., Montoro, L., López-Pérez, M. J., and Enríquez J. A. Human mtDNA haplogroups associated with high or reduced spermatozoa motility.
American Journal of Human Genetics
67:
682–696; 2000.

The dual genomic control system (co-adaptation)

Ballard, J. W. O., and Whitlock, M. C. The incomplete natural history of mitochondria.
Molecular Ecology
13:
729–744; 2004.

Blier, P. U., Dufresne, F., and Burton, R. S. Natural selection and the evolution of mtDNA-encoded peptides: Evidence for intergenomic co-adaptation.
Trends in Genetics
17:
400–406; 2001.

Ross, I. K. Mitochondria, sex and mortality.
Annals of the New York Academy of Sciences
1019:
581–584; 2004.

The mitochondrial bottleneck

Barritt, J. A., Brenner, C. A., Cohen, J., and Matt, D. W. Mitochondrial DNA rearrangements in human oocytes and embryos.
Molecular Human Reproduction
5:
927–933; 1999.

Cummins, J. M. The role of mitochondria in the establishment of oocyte functional competence.
European Journal of Obstetrics and Gynecology and Reproductive Biology
115S:
S23–S29; 2004.

Jansen, R. P. S. Germline passage of mitochondria: Quantitative considerations and possible embryological sequelae.
Human Reproduction
15
(suppl. 2): 112–128; 2000.

Krakauer, D. C., and Mira, A. Mitochondria and germ-cell death.
Nature
400:
125–126; 1999.

Perez, G. I., Trbovich, A. M., Gosden, R. G., and Tilly, J. L. Mitochondria and the death of oocytes.
Nature
403:
500–501; 2000.

Part 7
General texts

Halliwell, B., and Gutteridge, J.
Free Radicals in Biology and Medicine
. Oxford University Press, Oxford, UK, 1999.

Holliday, Robin.
Understanding Ageing
. Cambridge University Press, Cambridge, UK, 1995.

Lane, Nick.
Oxygen: The Molecule that Made the World
. Oxford University Press, Oxford, UK, 2002.

Lifespan and metabolic rate

Barja, G. Mitochondrial free-radical production and aging in mammals and birds.

Annals of the New York Academy Sciences
854:
224–238; 1998.

Brunet-Rossinni, A. K., and Austad, S. N. Ageing studies on bats: A review.
Biogerontology
5:
211–222; 2004.

Skulachev, V. P. Mitochondria, reactive oxygen species and longevity: Some lessons from the Barja group.
Ageing Cell
3:
17–19; 2004.

Speakman, J. R., Selman, C., McLaren, J. S., and Harper, E. J. Living fast, dying when? The link between ageing and energetics.
Journal of Nutrition
132
(suppl. 2): 1583S–1597S; 2002.

Mitochondrial theory of ageing

Harman, D. The biologic clock: The mitochondria?
Journal of the American Geriatrics Society
20:
145–147; 1972.

Miquel, J., Economos, A. C., Fleming, J., and Johnson, J. E., Jr. Mitochondrial role in cell ageing.
Experimental Gerontology
15:
575–591; 1980.

Failure of antioxidants

Barja, G. Free radicals and aging.
Trends in Neurosciences
27:
595–600; 2004.

Cutler, R. G. Antioxidants and longevity of mammalian species.
Basic Life Sciences
35:
15–73; 1985.

Orr, W. C., Mockett, R. J., Benes J. J., and Sohal, R. S. Effects of overexpression of copper-zinc and manganese superoxide dismutases, catalase, and thioredoxin reductase genes on longevity in
Drosophila melanogaster
.
Journal of Biological Chemistry
278:
26418–26422; 2003.

Mitochondrial diseases

Chinnery, P. F., DiMauro, S., Shanske, S., et al. Risk of developing a mitochondrial DNA deletion disorder.
Lancet
364:
591–596; 2004.

Fernández-Moreno, M., Bornstein, B., Petit, N., and Garesse, R. The pathophysiology of mitochondrial biogenesis: Towards four decades of mitochondrial DNA research.
Molecular Genetics and Metabolism
71:
481–495; 2000.

Marx, J. Metabolic defects tied to mitochondria gene.
Science
306:
592–593; 2004.

Schapira, A. Mitochondrial DNA and disease.
The Biochemist
27(3):
24–27; 2005.

Wallace, D. C. Mitochondrial diseases in man and mouse.
Science
283:
1482–1488; 1999.

Mitochondrial mutations in ageing

Coskun, P. E., Ruiz-Pesini, E., and Wallace, D. C. Control region mtDNA variants: Longevity, climatic adaptation, and a forensic conundrum.
Proceedings of the National Academy of Sciences USA
100:
2174–2176; 2003.

Lightowlers, R. N., Jacobs, H. T., and Kajander, O. A. Mitochondrial DNA—all things bad?
Trends in Genetics
15:
91–93; 1999.

Linnane, A. W., Marzuki, S., Ozawa, T., and Tanaka, M. Mitochondria DNA mutations as an important contributor to ageing and degenerative diseases.
Lancet
1 (8639):
642–645; 1989.

Michikawa, Y., Mazzucchelli, F., Bresolin, N., Scarlato, G., and Attardi, G. Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication.
Science
286:
774–779; 1999.

Zhang, J., Asin-Cayuela, J., Fish, J., Michikawa, Y., Bonafè, M., Olivieri, F., Passarino, G., De Benedictis, G., Franceschi, C., and Attardi, G. Strikingly higher frequency in centenarians and twins of mtDNA mutation causing remodeling of replication origin in leukocytes.
Proceedings of the National Academy of Sciences USA
100:
1116–1121; 2003.

Redox signalling in mitochondria

Allen, J. F. Control of gene expression by redox potential and the requirement for chloroplast and mitochondrial genes.
Journal of Theoretical Biology
165:
609–631; 1993.

—— The function of genomes in bioenergetic organelles.
Philosophical Transactions of the Royal Society of London B: Biological Sciences
358:
19–38; 2003.

Landar, A. L., Zmijewski, J. W., Oh, J. Y., and Darley Usmar, V. M. Message from the cell’s powerhouse.
The Biochemist
27(3):
9–14; 2005.

The retrograde response

Butow, R. A., and Avadhani, N. G. Mitochondrial signaling: The Retrograde response.
Molecular Cell
14:
1–15; 2004.

De Benedictis, G., Carrieri, G., Garastro, S., Rose, G., Varcasia, O., Bonafè, M., Franceschi, C., and Jazwinski, S. M. Does a retrograde response in human aging and longevity exist?
Experimental Gerontology
35:
795–801; 2000.

Apoptosis and neurodegenerative diseases

Coskun, P. E., Ruiz-Pesini, E., and Wallace, D. C. Control region mtDNA variants: Longevity, climatic adaptation, and a forensic conundrum.
Proceedings of the National Academy of Sciences USA
100:
2174–2176; 2003.

Wright, A. F., Jacobson, S. G., Cideciyan, A. V., Roman, A. J., Shu, X., Vlachantoni, D, McInnes, R. R., and Riemersma, R. A. Lifespan and mitochondrial control of neuro-degeneration.
Nature Genetics
36:
1153–1158; 2004.

Proof-reading in mice

Balaban, R. S., Nemoto, S., and Finkel, T. Mitochondria, oxidants, and aging.
Cell
120:
483–495; 2005.

Trifunovic, A., Wredenberg, A., Falkenberg, M., Spelbrink, J. N., Rovio, A. T., Bruder, C. E., Bohlooly-Y, M., Gidlof, S., Oldfors, A., Wibom, R., Tornell, J., Jacobs, H. T., and Larsson, N. G. Premature ageing in mice expressing defective mitochondrial polymerase.
Nature
429:
417–423; 2004.

Source of leakage at complex I

Herrero, A., and Barja, G. Localization of the site of oxygen radical generation inside complex I of heart and nonsynaptic brain mammalian mitochondria.
Journal of Bioenergetics and Biomembranes
32:
609–615; 2000.

Kushnareva, Y., Murphy, A. N., and Andreyev, A. Complex I-mediated reactive oxygen species generation: Modulation by cytochrome c and NAD(P)
+
oxidation state.
Biochemical Journal
368:
545–553; 2002.

Japanese centenarians

Tanaka, M., Gong, J. S., Zhang, J., Yoneda, M., and Yagi, K. Mitochondrial genotype associated with longevity.
Lancet
351:
185–186; 1998.

—— —— —— Yamada, Y., Borgeld, H. J., and Yagi, K. Mitochondrial genotype associated with longevity and its inhibitory effect on mutagenesis.
Mechanisms of Ageing and Development
116:
65–76; 2000.

Uncoupling, ageing and obesity

Ruiz-Pesini, E., Mishmar, D., Brandon, M., Procaccio, V., and Wallace, D. C. Effects of purifying and adaptive selection on regional variation in human mtDNA.
Science
303:
223–226; 2004.

Speakman, J. R., Talbot, D. A., Selman, C., Snart, S., McLaren, J. S., Redman, P., Krol, E., Jackson, D. M., Johnson, M. S., and Brand, M. D. Uncoupled and surviving: Individual mice with high metabolism have greater mitochondrial uncoupling and live longer.
Aging Cell
3:
87–95; 2004.

Exercise paradox

Herrero, A., and Barja, G. ADP-regulation of mitochondrial free-radical production is different with complex I- or complex II-linked substrates: Implications for the exercise paradox and brain hypermetabolism.
Journal of Bioenergetics and Biomembranes
29:
241–249; 1997.

Calorie restriction and free-radical leakage

Gredilla, R., Barja, G., and López-Torres, M. Effect of short-term caloric restriction on
H
2
O
2
production and oxidative DNA damage in rat liver mitochondria and location of the free radical source.
Journal of Bioenergetics and Biomembranes
33:
279–287; 2001.

Sex versus survival

Kirkwood, T. B., and Rose, M. R. Evolution of senescence: Late survival sacrificed for reproduction.
Philosophical Transactions of the Royal Society of London B: Biological Sciences
332:
15–24; 1991.

Aerobic capacity of birds

Maina, J. N. What it takes to fly: The structural and functional respiratory refinements in birds and bats.
Journal of Experimental Biology
203:
3045–3064; 2000.

Index
 

Italic numbers denote references to illustrations. References to footnotes are followed by ‘n.’.

absorption spectra, respiratory pigments 74–5

ADP (adenosine diphosphate) 79;
see also
ATP (adenosine triphosphate)

aerobic capacity hypothesis (evolution of endothermy) 180–5

aerobic scope 168–70

African Eve 3, 242, 246, 251

ageing:

cell loss 303

exercise paradox 273, 306

free-radical leakage 272–3, 274–5, 277, 303–11

metabolic rate 158, 269–70, 272

mitochondrial mutations 284–8, 296–301

mitochondrial theory of 4, 272–301

theories of 272–3

see also
lifespan

age-related (degenerative) diseases 4, 270, 271–2, 295–301, 303

algae, evolution of 25

Allen, John 138, 143–4,
144
, 289–90

Altmann, Richard 12–13

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