Mosby's 2014 Nursing Drug Reference (86 page)

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TREATMENT OF ANAPHYLAXIS:

EPINEPHrine, antihistamines; resuscitate if needed

Canada only   Side effects:
italics
= common;
bold
= life-threatening   
Nurse Alert

CEPHALOSPORINS—
3RD/4TH GENERATION
cefdinir (Rx)

(sef′dih-ner)

Omnicef

cefditoren pivoxil (Rx)

(sef-dit′oh-ren pih-vox′il)

Spectracef

cefepime (Rx)

(sef′e-peem)

Maxipime (4th generation)

cefixime (Rx)

(sef-icks′ime)

Cefixime, Suprax

cefotaxime (Rx)

(sef-oh-taks′eem)

Claforan

cefpodoxime (Rx)

(sef-poe-docks′eem)

Vantin

cefTAZidime (Rx)

(sef′tay-zi-deem)

Ceptaz, Fortaz, Tazicef, Tazidime

ceftibuten (Rx)

(sef-ti-byoo′tin)

Cedax

ceftizoxime (Rx)

(sef-ti-zox′eem)

Cefizox

cefTRIAXone (Rx)

(sef-try-ax′one)

Rocephin

Func. class.:
Broad-spectrum antibiotic

Chem. class.:
Cephalosporin (3rd generation)

Do not confuse:
cefTAZidime
/ceftizoxime
Vantin
/Ventolin

ACTION:

Inhibits bacterial cell wall synthesis, renders cell wall osmotically unstable, leads to cell death

USES:

cefdinir:
Community-acquired pneumonia, otitis media, sinusitis, pharyngitis, skin and skin-structure infections, acute exacerbations of chronic bronchitis, gram-negative bacilli:
Haemophilus influenzae, Haemophilus parainfluenzae, Moraxella catarrhalis;
gram-positive organisms:
Streptococcus pneumoniae, Streptococcus pyogenes, Staphylococcus aureus
(MSSA)

cefditoren pivoxil:
Acute bacterial exacerbations of chronic bronchitis caused by 
Haemophilus influenzae, Haemophilus parainfluenzae, Streptococcus pneumoniae, Moraxella catarrhalis
; pharyngitis/tonsillitis caused by
Streptococcus pyogenes
; uncomplicated skin and skin-structure infections caused by
Staphylococcus aureus, Streptococcus pyogenes;
community-acquired pneumonia

cefepime:
Gram-negative bacilli:
Escherichia coli, Proteus, Klebsiella;
gram-positive organisms:
Streptococcus pneumoniae, Streptococcus pyogenes, Staphylococcus aureus;
lower respiratory tract, urinary tract, skin, bone infections; febrile neutropenia intraabdominal infection

cefixime:
Uncomplicated UTI
(Escherichia coli, Proteus mirabilis)
, pharyngitis and tonsillitis
(Streptococcus pyogenes)
, otitis media
(Haemophilus influenzae), Moraxella catarrhalis
, acute bronchitis and acute exacerbations of chronic bronchitis
(Streptococcus pneumoniae, H. influenzae)
, uncomplicated gonorrhea

cefotaxime:
Gram-negative organisms:
Haemophilus influenzae, Haemophilus parainfluenzae, Escherichia coli, Enterococcus faecalis, Neisseria gonorrhoeae, Neisseria meningitidis, Proteus mirabilis, Klebsiella, Citrobacter, Serratia, Salmonella, Shigella Pseudomonas;
gram-p
ositive organisms:
Streptococcus pneumoniae, Streptococcus pyogenes, Staphylococcus aureus;
serious lower respiratory tract, urinary tract, skin, bone, gonococcal infections; bacteremia, septicemia, meningitis, skin, skin-structure infections; CNS infections; perioperative prophylaxis

cefpodoxime:
Gram-negative bacilli:
Neisseria gonorrhoeae, Haemophilus influenzae, Escherichia coli, Proteus mirabilis, Klebsiella;
gram-positive organisms:
Streptococcus pneumoniae, Streptococcus pyogenes, Staphylococcus aureus;
upper and lower respiratory tract, urinary tract, skin infections; otitis media; sexually transmitted diseases

cefTAZidime:
Gram-negative organisms:
Haemophilus influenzae, Escherichia coli, Enterobacter aerogenes, Pseudomonas aeruginosa, Proteus mirabilis, Klebsiella, Citrobacter, Enterobacter, Salmonella, Shigella, Acinetobacter, Bacteroides fragilis, Neisseria, Serratia;
gram-positive organisms:
Streptococcus pneumoniae, Streptococcus pyogenes, Staphylococcus aureus;
serious upper/lower respiratory tract, urinary tract, skin, gynecologic, bone, joint, intraabdominal infections; septicemia, meningitis, febrile neutropenia

ceftibuten:
Pharyngitis/tonsillitis, otitis media, secondary bacterial infection of acute bronchitis

ceftizoxime:
Gram-negative bacilli:
Haemophilus influenzae, Escherichia coli, Enterobacter aerogenes, Proteus mirabilis, Klebsiella, Enterobacter;
gram-positive organisms:
Streptococcus pneumoniae, Streptococcus pyogenes, Staphylococcus aureus;
serious lower respiratory tract, urinary tract, skin, intraabdominal infections; septicemia, meningitis, bone, joint infections; PID caused by
Neisseria gonorrhoeae

cefTRIAXone:
Gram-negative bacilli:
Haemophilus influenzae, Escherichia coli, Enterobacter aerogenes, Proteus mirabilis, Klebsiella, Citrobacter, Enterobacter, Salmonella, Shigella, Acinetobacter, Bacteroides fragilis, Neisseria, Serratia;
gram-positive organisms:
Streptococcus pneumoniae, Streptococcus pyogenes, Staphylococcus aureus;
serious lower respiratory tract, urinary tract, skin, gonococcal, intraabdominal infections; septicemia, meningitis, bone, joint infections; otitis media; PID

CONTRAINDICATIONS:

Hypersensitivity to cephalosporins, infants <1 mo

Precautions:
Pregnancy (B), breastfeeding, children, hypersensitivity to penicillins, GI/renal disease

DOSAGE AND ROUTES
Calculator
cefdinir
Uncomplicated skin and skin-structure infections/community-acquired pneumonia

• Adult and child ≥13 yr:
PO
300 mg q12hr × 10 days

• Child 6 mo-12 yr:
PO
7 mg/kg q12hr or 14 mg/kg q24hr × 10 days

Acute exacerbations of chronic bronchitis/acute maxillary sinusitis

• Adult and child ≥13 yr:
PO
300 mg q12hr or 600 mg q24hr × 10 days or 300 mg bid × 5 days for some infections

Pharyngitis/tonsillitis

• Adult and child ≥13 yr:
PO
300 mg q12hr or 600 mg q24hr × 10 days

• Child 6 mo-12 yr:
PO
7 mg/kg q12hr × 5-10 days or 14 mg/kg q24hr × 10 days

Renal dose

• 
CCr <30 ml/min, 300 mg/day (adult); 7 mg/kg/day (child)

Available forms:
Caps 300 mg; susp 125 mg, 250 mg/5 ml

cefditoren pivoxil

• Adult:
PO
200-400 mg bid × 10 days

Renal dose

• Adult:
PO
CCr 30-50 ml/min, max 200 mg bid; CCr <30 ml/min, max 200 mg daily

Available forms:
Tabs 200 mg

cefepime
Febrile neutropenia

• Adult/adolescent >16 yrs/child ≥ 40 kg:
IV
2 g q8hr × 7 days or until neutropenia resolves

• Infant ≥2 mo/child/adolescent ≤16 yr and ≤40 kg:
IV
50 mg/kg/dose q8hr × 7-10 days or until neutropenia resolves

Urinary tract infections (mild to moderate)

• Adult:
IV/IM
0.5-1 g q12hr × 7-10 days

Urinary tract infections (severe)

• Adult/adolescent >16 yr/child ≥40 kg:
IV
2 g q12hr × 10 days

Pneumonia (moderate to severe)

• Adult:
IV
1-2 g q12hr × 10 days

• 
Dosage reduction indicated with renal impairment (CCr <50 ml/min)

Uncomplicated gonorrhea

• 
IM
2 g as a single dose with 1 g
PO
probenecid at the same time

Available forms:
Powder for inj 500 mg, 1, 2 g; 1 g/50 ml, 2 g/100 ml

cefixime

• Adult:
PO
400 mg/day as a single dose or 200 mg q12hr

• Child >50 kg or >12 yr:
PO
use adult dosage

• Child <50 kg or <12 yr:
PO
8 mg/kg/day as a single dose or 4 mg/kg q12hr

Renal dose

• 
CCr 21-60 ml/min, give 75% of dose; CCr <20 ml/min, give 50% of dose

Available forms:
Tabs 400 mg; powder for oral susp 100 mg/5 ml, chew tabs 100, 200 mg, 200 mg/5 ml

cefotaxime

• Adult:
IM/IV
1-2 g q12hr

• Child 1 mo-12 yr:
IM/IV
50-180 mg/kg/day divided q6hr

Severe infections

• Adult:
IM/IV
2 g q4hr not to exceed 12 g/day

• Child 1 mo-12 yr:
IM/IV
50-180 mg/kg/day in 4-6 divided doses

Uncomplicated gonorrhea

• Adult:
IM
1 g

• 
Dosage reduction indicated for severe renal impairment (CCr <30 ml/min)

Available forms:
Powder for inj 500 mg, 1, 2, 10 g; inj 1, 2 g premixed frozen

cefpodoxime
Pneumonia

• Adult >13 yr:
PO
200 mg q12hr × 14 days

Uncomplicated gonorrhea

• Adult >13 yr:
PO
200 mg as a single dose

Skin and skin structure

• Adult >13 yr:
PO
400 mg q12hr × 7-14 days

Pharyngitis and tonsillitis

• Adult >13 yr:
PO
100 mg q12hr × 10 days

• Child 5 mo-12 yr:
PO
5 mg/kg q12hr (max 100 mg/dose or 200 mg/day) × 5-10 days

Uncomplicated UTI

• Adult >13 yr:
PO
100 mg q12hr × 7 days; dosing interval increased with severe renal impairment

Acute otitis media

• Child 5 mo-12 yr:
PO
5 mg/kg q12hr × 10 days

Available forms:
Tabs 100, 200 mg; granules for susp 50 mg, 100 mg/5 ml

cefTAZidime

• Adult:
IV/IM
1-2 g q8-12hr × 5-10 days

• Child:
IV
30-50 mg/kg q8hr, max 6 g/day

• Neonate:
IV
30-50 mg/kg q12hr

Renal dose

• Adult:
IM/IV
CCr <50 ml/min, give q12hr; CCr 10-30 ml/min, give q24hr; CCr <10 ml/min, give q48-72hr

Available forms:
Inj 250, 500 mg, 1, 2, 6 g

ceftibuten

• Adult:
PO
400 mg/day × 10 days

• Child 6 mo-12 yr:
PO
9 mg/kg/day × 10 days

Renal dose

• Adult:
PO
CCr 30-49 ml/min, give 200 mg q24hr; CCr 5-29 ml/min, give 100 mg q24hr

Available forms:
Caps 400 mg; susp 90 mg, 180 mg/5 ml

ceftizoxime

• Adult:
IM/IV
1-2 g q8-12hr, may give up to 4 g q8hr in life-threatening infections

• Child >6 mo:
IM/IV
50 mg/kg q6-8hr

Renal dose

• Adult:
IM/IV
CCr <50-80 ml/min, give 500-1500 mg q8hr; CCr 5-49 ml/min, give 250-1000 mg q12hr

PID

• Adult:
IV
2 g q8hr, may increase to 4 g q8hr in severe infections

Available forms:
Powder for inj 500 mg, 1, 2, 10 g; premixed 1 g, 2 g/50 ml

cefTRIAXone

• Adult:
IM/IV
1-2 g/day, max 2 g q12-24hr

• Child:
IM/IV
50-75 mg/kg/day in equal doses q12hr

Uncomplicated gonorrhea

• Adult:
250 mg
IM
as single dose

• 
Reduce dosage in severe renal impairment (CCr <10 ml/min)

Meningitis

• Adult and child:
IM/IV
100 mg/kg/day in equal doses q12hr, max 4 g/day

Surgical prophylaxis

• Adult:
IV
1 g 1/2-2 hr before surgery

Available forms:
Inj 250, 500 mg, 1, 2, 10 g

Administer:

• 
Change IV site q72hr

cefdinir

• 
Oral susp after adding 39 ml water to the 60-ml bottle or 65 ml water to the 120-ml bottle; discard unused portion after 10 days; give without regard to food, do not give within 2 hr of antacids, iron supplements

• 
After C&S completed

cefditoren pivoxil

• 
For 10 days to ensure organism death, prevent superinfection

• 
With food for GI symptoms, do not give with antacids

• 
After C&S completed

cefepime
Intermittent IV INF route

• 
IV after diluting in 50-100 ml or more D
5
, NS; give over 30 min

• 
For 7-10 days to ensure organism death, prevent superinfection

Solution compatibilities:
0.9% NaCl, D
5
, D
5
W, 0.5%, 10% lidocaine, bacteriostatic water for inj with parabens/benzyl alcohol

Y-site compatibilities:
DOXOrubicin liposome

cefixime

• 
For 10-14 days to ensure organism death, prevent superinfection

• 
Do not break, crush, or chew tab

• 
Without regard to food

cefotaxime
IV route

• 
IV after
diluting
1 g/10 ml D
5
W, NS, sterile water for inj,
give
over 3-5 min by
Y
-tube or 3-way stopcock; may be
diluted further
with 50-100 ml NS or D
5
W;
run
over 1/2-1 hr; discontinue primary inf during administration; may be
diluted
in larger vol of sol, given as a cont inf over 6-24 hr

• 
For 10-14 days to ensure organism death, prevent superinfection

• 
Thaw frozen container at room temp or refrigeration; do not force thaw by immersion or microwave; visually inspect container for leaks

Syringe compatibilities:
Caffeine, diphenhyDRINATE, heparin, ofloxacin

Y-site compatibilities:
Acyclovir, alfentanil, alprostadil, amifostine, amikacin, aminocaproic acid, aminophylline, anidulafungin, ascorbic acid injection, atenolol, atracurium, atropine, aztreonam, benztropine, bivalirudin, bleomycin, bumetanide, buprenorphine, butorphanol, caffeine, calcium chloride/gluconate, CARBOplatin, cefamandole, cefmetazole, cefonicid, cefoperazone, cefoTEtan, cefOXitin, cefTAZidime (L-arginine), cefTRIAXone sodium, cefuroxime, cimeti
dine, CISplatin, clindamycin, codeine, cyanocobalamin, cyclophosphamide, cycloSPORINE, cytarabine, DACTINomycin, DAPTOmycin, dexamethasone, dexmedetomidine, digoxin, diltiazem, DOCEtaxel, DOPamine, doxacurium, doxycycline, enalaprilat, ePHEDrine, EPINEPHrine, epirubicin, epoetin alfa, eptifibatide, erythromycin, esmolol, etoposide, famotidine, fenoldopam, fentaNYL, fludarabine, fluorouracil, folic acid, furosemide, gatifloxacin, gentamicin, glycopyrrolate, granisetron, heparin, hydrocortisone, HYDROmorphone, ifosfamide, imipenem-cilastatin, insulin (regular), isoproterenol, ketorolac, lidocaine, linezolid, LORazepam, LR, magnesium sulfate, mannitol, mechlorethamine, melphalan, meperidine, metaraminol, methicillin, methotrexate, methoxamine, methyldopate, metoclopramide, metoprolol, metroNIDAZOLE, mezlocillin, miconazole, midazolam, milrinone, minocycline, mitoXANtrone, morphine, moxalactam, multiple vitamins, mycophenolate, nafcillin, nalbuphine, naloxone, nesiritide, netilmicin, nitroglycerin, nitroprusside, norepinephrine, normal saline, octreotide, ofloxacin, ondansetron, ornidazole, oxacillin, oxaliplatin, oxytocin, PACLitaxel, palonosetron, pamidronate, pancuronium, pantoprazole, papaverine, pefloxacin, pemetrexed, penicillin G potassium/sodium, pentamidine, pentazocine, PENTobarbital, peritoneal dialysis solution, perphenazine, PHENobarbital, phenylephrine, phenytoin, phytonadione, piperacillin, polymyxin B, potassium chloride, procainamide, prochlorperazine, promethazine, propofol, propranolol, protamine, pyridoxine, quiNIDine, quinupristin, ranitidine, remifentanil, Ringer’s injection, ritodrine, riTUXimab, rocuronium, sargramostim, sodium acetate/bicarbonate, sodium fusidate, sodium lactate, succinylcholine, SUFentanil, sulfamethoxazole-trimethoprim, tacrolimus, teniposide, theophylline, thiamine, thiotepa, ticarcillin, ticarcillin-clavulanate, tigecycline, tirofiban, TNA, tobramycin, tolazoline, TPN, trastuzumab, trimetaphan, urokinase, vancomycin, vasopressin, vecuronium, verapamil, vinorelbine, voriconazole

cefpodoxime

• 
Do not break, crush, or chew tabs due to taste

• 
For 10-14 days to ensure organism death, prevent superinfection

• 
With food for better absorption; do not give within 2 hr of antacids, H
2
-receptor antagonists

cefTAZidime
IM route

• 
Fortaz, Tazidime vials:
Reconstitute 500 mg or 1 g with 1.5 or 3 ml, respectively, of sterile or bacteriostatic water for inj or 0.5-1% lidocaine (approx 280 mg/ml)

• 
Tazicef vials:
Reconstitute 1 g/3 ml sterile water for inj (approx 280 mg/ml)

• 
Ceptaz vials:
Reconstitute 1 g/3 ml sterile or bacteriostatic water for inj or 0.5-1% lidocaine (approx 250 mg/ml)

• 
Withdraw
dose while making sure needle remains in vial;
ensure
no CO
2
bubbles present;
inject
deeply in large muscle mass,
aspirate
before injection

IV route

• 
Visually inspect for particulate matter, discoloration, if possible

• 
Fortaz, Tazicef, Tazidime packs: Reconstitute
1 or 2 g/100 ml sterile water for inj or other compatible IV sol (10 or 20 mg/ml, respectively); reconstitution is done in two stages: first,
inject
10 ml of the diluent into the pack and
shake
well to dissolve and become clear; CO
2
pressure inside container will occur,
insert
vent needle to release pressure;
add
remaining diluents,
remove
vent needle

• 
Fortaz, Tazicef, Tazidime vials: Reconstitute
500 mg, 1 g, 2 g with 5, 10, 10 ml, respectively, of sterile water for inj or other compatible IV solution (100, 95-100, or 170-180 mg/ml, respectively);
shake
well to dissolve

• 
Fortaz, Tazidime ADD-Vantage vials (for IV only): Reconstitute
1 or 2 g with NS, ½ NS, D
5
W in either 50- or 100-ml flexible diluent container; to release
CO
2
pressure,
insert
vent needle after dissolving,
remove
vent before using

• 
Ceptaz packs: Reconstitute
1 or 2 g/100 ml sterile water for inj or compatible IV sol (10 or 20 mg/ml, respectively); reconstitution is done in two stages: first,
inject
10 ml of the diluent into the pack and
shake
well to dissolve,
add
the remaining diluent,
insert
vent needle before giving

• 
Ceptaz vials: Reconstitute
1 or 2 g/10 ml of sterile water for inj or compatible IV sol (90-95, or 170-180 mg/ml, respectively)

• 
Ceptaz ADD-Vantage vials (for IV only): Reconstitute
1 or 2 g with NS, ½ NS, or D
5
W in either 50- or 100-ml diluent container

Direct intermittent IV INF route

• 
Vials: withdraw
dose while making sure needle remains in sol; make sure there are no CO
2
bubbles in syringe before inj;
inject
directly over 3-5 min or slowly into tubing of a free-flowing compatible IV solution

Intermittent IV INF route

• 
Vials: withdraw
dose while making sure needle opening remains in sol; make sure there are no CO
2
bubbles in syringe before inj; infusion packs and ADD-Vantage systems ready for inf after reconstitution,
infuse
over 15-30 min

Syringe compatibilities:
Cimetidine, dimenhyDRINATE, HYDROmorphone

Y-site compatibilities:
Acyclovir, alfentanil, allopurinol, amifostine, amikacin, aminocaproic acid, aminophylline, amphotericin B lipid complex, anakinra, anidulafungin, atenolol, atropine sulfate, aztreonam, benzotropine, bivalirudin, bleomycin, bumetanide, buprenorphine, butorphanol, calcium gluconate, CARBOplatin, cefamandole, ceFAZolin, cefonicid, cefoperazone, cefoTEtan, cefOXitin, cefTAZidime, ceftizoxime, cefTRIAXone, cefuroxime, cephalothin, cephapirin, cimetidine, ciprofloxacin, CISplatin, clindamycin, codeine, cyanocobalamin, cyclophosphamide, cycloSPORINE, cytarabine, DACTINomycin, DAPTOmycin, dexamethasone, dexmedetomidine, digoxin, diltiazem, DOCEtaxel, DOPamine, doxacurium, doxapram, enalaprilat, ePHEDrine, EPINEPHrine, epoetin alfa, eptifibatide, esmolol, etoposide, famotidine, fenoldopam, fentaNYL, filgrastim, fludarabine, fluorouracil, folic acid, foscarnet, furosemide, gallium, gatifloxacin, gemcitabine, gentamicin, glycopyrrolate, granisetron, heparin, HYDROmorphone, ifosfamide, imipenem-cilastatin, indomethacin, insulin (regular), irinotecan, isepamicin, isoproterenol, isosorbide, ketamine, ketorolac, labetalol, levofloxacin, lidocaine, linezolid, LORazepam, LR, magnesium sulfate, mannitol, mechlorethamine, melphalan, meperidine, metaraminol, methicillin, methotrexate, methoxamine, methyldopate, methylPREDNISolone, metoclopramide, metoprolol, metroNIDAZOLE, miconazole, milrinone, morphine, moxalactam, multiple vitamin inj, nafcillin, nalbuphine, PACLitaxel, ranitidine, remifentanil, tacrolimus, teniposide, theophylline, thiotepa, vinorelbine, zidovudine

ceftibuten

• 
For 10 days to ensure organism death, prevent superinfection

• 
Without regard to food

ceftizoxime
IV route

• 
IV after
diluting
1 g/10 ml sterile water, shake and
give
over 3-5 min; may be
diluted further
with 50-100 ml NS or D
5
W; give through
Y
-tube or 3-way stopcock;
run
over 1/2-1 hr

• 
For 10-14 days to ensure organism death, prevent superinfection

Y-site compatibilities:
Acyclovir, alfentanil, allopurinol, amifostine, amikacin, aminocaproic acid, aminophylline, amiodarone, amphotericin B cholesteryl, amphotericin B liposome, anidulafungin, ascorbic acid injection, atenolol, atracurium, atropine, aztreonam, benztropine, bivalirudin, bleomycin, bumetanide, buprenorphine, butorphanol, calcium chloride/gluconate, CARBOplatin, caspofungin, cefamandole, ceFAZolin, cefmet
azole, cefoperazone, cefoTEtan, cefTAZidime, cefTRIAXone, cefuroxime, cephalothin, cephapirin, cimetidine, CISplatin, clindamycin, codeine, cyanocobalamin, cyclophosphamide, cycloSPORINE, cytarabine, DACTINomycin, DAPTOmycin, dexamethasone, dexmedetomidine, digoxin, diltiazem, diphenhydrAMINE, DOCEtaxel, DOPamine, doxacurium, DOXOrubicin, DOXOrubicin liposomal, enalaprilat, ePHEDrine, EPINEPHrine, epirubicin, epoetin alfa, eptifibatide, esmolol, etoposide, fenoldopam, fentaNYL, fluconazole, fludarabine, fluorouracil, folic acid, foscarnet, furosemide, gatifloxacin, gemcitabine, gentamicin, glycopyrrolate, granisetron, heparin, hydrocortisone, HYDROmorphone, IDArubicin, ifosfamide, imipenem-cilastatin, insulin (regular), irinotecan, isoproterenol, ketorolac, labetalol, levofloxacin, lidocaine, linezolid, LORazepam, LR, magnesium sulfate, mannitol, mechlorethamine, melphalan, meperidine, methotrexate, methoxamine, methyldopate, metoclopramide, metoprolol, metroNIDAZOLE, mezlocillin, midazolam, milrinone, mitoXANtrone, morphine, multiple vitamins injection, mycophenolate mofetil, nafcillin, naloxone, nesiritide, netilmicin, niCARdipine, nitroglycerin, nitroprusside, norepinephrine, octreotide, ondansetron, oxaliplatin, oxytocin, PACLitaxel, palonosetron, pamidronate, pancuronium, pantoprazole, PEMEtrexed, penicillin G potassium/sodium, PHENobarbital, phenylephrine, phytonadione, piperacillin, polymyxin B, potassium chloride, propofol, propranolol, ranitidine, remifentanil, Ringer’s, ritodrine, riTUXimab, rocuronium, sargramostim, sodium acetate/bicarbonate, succinylcholine, SUFentanil, tacrolimus, teniposide, theophylline, thiotepa, ticarcillin-clavulanate, tigecycline, tirofiban, TNA, tobramycin, TPN, trastuzumab, trimetaphan, vasopressin, verapamil, vinCRIStine, vinorelbine, voriconazole

cefTRIAXone

• 
For 10-14 days to ensure organism death, prevent superinfection

• 
IM
inj deeply in large muscle mass

IV route

• 
IV
after
diluting
250 mg/2.4 ml D
5
W, water for inj, 0.9% NaCl; may be
further diluted
with 50-100 ml NS, D
5
W, D
10
W; shake;
run
over 1/2-1 hr

• 
Do not mix with calcium salts

Y-site compatibilities:
Acyclovir, alfentanil, allopurinol, amifostine, amikacin, aminocaproic acid, aminophylline, amiodarone, amphotericin B liposome, anidulafungin, atenolol, atracurium, atropine, aztreonam, benztropine, bivalirudin, bleomycin, bumetanide, buprenorphine, butorphanol, CARBOplatin, cefamandole, ceFAZolin, cefmetazole, cefonicid, cefoperazone, cefoTAXime, cefoTEtan, cefOXitin, cefTAZidime, ceftizoxime, cefuroxime, cephalothin, cephapirin, cimetidine, cisatracurium, CISplatin, codeine, cyanocobalamin, cyclophosphamide, cycloSPORINE, cytarabine, DACTINomycin, DAPTOmycin, dexamethasone, dexmedetomidine, digoxin, diltiazem, DOCEtaxel, DOPamine, doxacurium, DOXOrubicin liposomal, doxycycline, drotrecogin alfa, enalaprilat, ePHEDrine, EPINEPHrine, epoetin alfa, eptifibatide, erythromycin, esmolol, etoposide, fenoldopam, fludarabine, fluorouracil, folic acid, foscarnet, furosemide, gallium, gatifloxacin, gemcitabine, gentamicin, glycopyrrolate, granisetron, heparin, hydrocortisone, HYDROmorphone, ifosfamide, indomethacin, insulin (regular), isoproterenol, ketorolac, lansoprazole, levofloxacin, lidocaine, linezolid, LORazepam, mannitol, mechlorethamine, melphalan, meperidine, metaraminol, methicillin, methotrexate, methoxamine, methyldopate, methylPREDNISolone, metoclopramide, metoprolol, metroNIDAZOLE, mezlocillin, miconazole, midazolam, milrinone, morphine, moxalactam, multiple vitamins injection, nafcillin, nalbuphine, naloxone, nesiritide, netilimicin, nitroglycerin, nitroprusside, norepinephrine, octreotide, oxacillin, oxaliplatin, oxytocin, PACLitaxel, palonosetron, pamidro
nate, pancuronium, pantoprazole, PEMEtrexed, penicillin G potassium/sodium, PHENobarbital, phenylephrine, phytonadione, piperacillin, polymyxin B, potassium chloride, procainamide, propofol, propranolol, pyridoxine, ranitidine, remifentanil, ritodrine, riTUXimab, rocuronium, sargramostim, sodium acetate/bicarbonate, succinylcholine, SUFentanil, tacrolimus, teniposide, theophylline, thiamine, thiotepa, ticarcillin, ticarcillin-clavulanate, tigecycline, tirofiban, tolazoline, trastuzumab, trimetaphan, urokinase, vasopressin, vecuronium, verapamil, vinCRIStine, voriconazole, warfarin, zidovudine

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