Covenant (26 page)

“Dr. Holloway?”

Dr. Graham Holloway was shorter than Tyrell and armed with quick, alert blue eyes and an aura of supreme confidence.

“Detective Tyrell,” he said, shaking Tyrell’s hand.

Tyrell introduced Lopez before looking down into the theater below. Eight surgeons surrounded a patient on the table, the theater filled with computers and complex-looking devices all connected to each other and the patient with a web of wires and tubes.

“What can I do for you?” Holloway asked.

“I understand that you’re the senior surgeon here,” Tyrell said, transfixed by the surgery below them.

“I’m the most experienced by years but there’s no real order of seniority.”

“Okay,” Tyrell said, opening his notebook. “When you perform surgery on your patients, how often is it necessary to put them into a
homeostatic
state?”

“Only when we’re required to perform deeply invasive brain surgery in hemorrhagic brain injuries or aggressive melanoma cases.”

“Cancer?” Lopez asked from one side.

“Yes. Very occasionally patients will be referred to us suffering from malignant tumors close to the brain stem or deep in the cerebral cortex.”

“And if you are required to perform such a procedure, you might bring the patient’s heartbeat down to a crawl,” Tyrell suggested. “How would you go about that?”

“There are several methods,” Holloway said, “but the principal ones include chemicals that relax the major organs. Another is via induced hypothermia.”

Tyrell caught Lopez’s look of surprise. Dr. Holloway didn’t miss the silent exchange. “It might help if you were to tell me what the problem is,” he suggested.

Tyrell nodded.

“We noticed some unusual pathology in the autopsies of three bodies discovered yesterday morning. All three had suffered from the early stages of hypothermia.” Tyrell saw Holloway raise his eyebrows at that. “You’re aware that it’s been nearly eighty degrees across the District over the past few days.”

“Go on,” the surgeon said quietly.

“The medical examiner confirmed that all three individuals showed excessive hydrogen sulphide in their blood.”

“Anything else?”

“All of the victims were of the same blood group, O-negative, but originally their blood had been AB, suggesting a transfusion.” Tyrell took a breath. “Given what I’ve just told you, what would be your best estimate of the kind of procedure that these individuals were subjected to?”

Holloway let out a long breath before speaking.

“It’s possible that a human body cooled using a saline solution to transfuse blood could suffer effects somewhat like frostbite if the procedure was poorly conducted.”

“They were actually frozen?” Lopez asked, mortified.

“Yes, it’s a common procedure developed to make open-heart surgery easier and is being enhanced for battlefield trauma victims and automobile accidents. By rapidly cooling the body using a chilled saline solution, a form of controlled hypothermia can be induced in the victim, slowing their metabolism to clinical death.”

“How does it work?” Tyrell asked.

“The patient is anesthetized, hooked up to a heart-bypass machine, and receives heparin, which is made from cow’s gut, to prevent blood clotting. The heart is then stopped via intravenously administered potassium chloride. The body is cooled over a period of about one hour to a temperature of around sixteen degrees Centigrade, essentially as cold as a corpse. We then drain the blood from the body and replace it with a chilled saline solution. By this time the patient is clinically dead, with no heartbeat, no blood, and no brain activity. Surgery is undertaken and when the work is complete the process is reversed, ending with a small electrical charge applied to the heart to initiate rhythm.”

“And this is done on a regular basis?” Lopez asked.

“Only in extreme cases to allow prolonged access to the brain or heart,” Holloway admitted. “Long-term hypothermic methods have only been conducted so far on dogs and mice in an experimental manner. The method was reported as having a success rate of better than eighty percent. The dogs even answered to their own names.”

“Eighty percent,” Lopez repeated softly. “And the other twenty?”

“Hard to tell in animals,” Holloway said, “but probably a condition similar to posttraumatic stress or schizophrenia. Mood swings and evidence of depression were noted, along with motor deficiency.”

Tyrell nodded, thinking furiously now.

“What about the altered blood group of the victims?”

“Entire blood transfusions are not uncommon,” Holloway said, “but would only occur to prevent rejection of foreign organs.”

Tyrell nodded, gathering his thoughts. “We have a survivor.”

“A what?”

“A twenty-one-year-old who survived this procedure. He’s suffering from paranoid schizophrenia and will be on antidepressants for the rest of his life. His mother told us that he and others were experimented on by physicians who, among other things, were attempting to extract and replace their blood. Many of the victims died. When we spoke to the medical examiner who examined the bodies we found, he said that the blood in their bodies was genetically unrecognizable, not human. One of the victims had suffered the extraction of reproductive tissues.”

Dr. Holloway’s face drained of color, turning almost as pale as the white of his coat. He looked from Tyrell to Lopez and back again.

“I can’t imagine what that would mean.”

“Try.”

“If you were to put a gun to my head and force me to suggest something, then the only thing that I can think of is that somebody was trying to use humans as incubators, perhaps to generate blood lines or stem cells for a chimera.”

Tyrell looked at Lopez, who had also paled. “What’s a chimera?”

Holloway spoke quietly.

“A species that is a combination of the genetic codes of two preceding species, a hybrid if you will.” Holloway paled again. “Whoever conducted those experiments is using human incubators in order to bring something back to life.”

W
hat do you mean, bring something back to life?”

Lopez watched as Dr. Holloway removed his spectacles and cleaned them as he spoke.

“With the recent advance of genetic science, it’s been possible to cross-breed two distinct species in order to create a half-breed, a chimera. It happens in nature quite a lot, but the more separated the two species are from their common ancestor, the less likely they are to be able to produce offspring.”

“But it’s been done,” Tyrell guessed.

“Oh yes. Sheep and goats produced a chimera, the so-called ‘Geep.’ Such interspecies are made in the laboratory by transplanting embryonic cells from an animal with one trait into the embryo of an animal with a different trait. This practice is common in the field.”

“So why would somebody want to conduct that procedure on humans?” Tyrell pressed.

“I really don’t know,” Holloway said. “But whatever the aim, the procedure would be highly illegal. In 2003, researchers at the Shanghai Second Medical University in China successfully fused human skin cells and dead rabbit eggs to create the first human chimeric embryos. The embryos were allowed to develop for several days in a laboratory setting, then destroyed to harvest the resulting stem cells. But from what you’re suggesting—”

“They’re using unwilling victims,” Tyrell said. “Which means that they’re probably taking things further than stem cells.”

“Could they produce another species if they had the required materials?” Lopez asked, clearly appalled by the thought of such genetic engineering.

“Absolutely.” Holloway nodded. “Though there would be a number of obstacles to overcome.”

“Such as?” Tyrell pressed.

“Well, the immune system would need to be repressed, which could explain the hypothermic cooling. Then there’s the fact that sperm and eggs of differing species won’t recognize each other, and the number of chromosomes won’t match, which will prevent effective fertilization. They would need to acquire stem cells from the species they’re trying to clone, or at least culture cells from existing material in order to produce viable embryos using host or donor cells, which could explain the surgery marks on some of your victims and …”

Dr. Holloway suddenly trailed off. Tyrell saw the doctor’s expression sag and his eyes fill with horror.

“What is it?” Tyrell asked.

Holloway shook his head, his voice throaty as he spoke.

“If they fertilized human eggs that had had their nucleus replaced with foreign stem cells, they could possibly create an embryo that could then be implanted into a host.”

Lopez winced.

“They can do that?”

“They could use bone-marrow stem cells,” Holloway said, “from the species they are trying to clone. From those cells all the various types of blood cells are descended, and using a laboratory can give rise to even non-marrow cells.”

“Like embryonic stem cells,” Tyrell suggested.

“It’s cloning, in effect.” Holloway nodded. “Whole cell or animal cloning occurs through the transfer of the nucleus of an adult cell into an enucleated egg. This can result in the reprogramming of the adult cell DNA to produce a cloned animal. They could create an extinct species, for instance, from the nucleus of a cultured mammary gland cell or similar that is then fused to a human egg cell that has had its own nucleus removed. The fused cell can then be implanted into a female human host. Nuclear transfer has been applied to produce cloned animals like cows, goats, pigs, mice, cats, and so on.”

“What, you mean impregnated in vitro?”

Holloway nodded, his features twisted with distaste.

“In the 1920s, Joseph Stalin sent an animal-breeding expert to Africa in hopes of creating an army of half-man, half-monkey soldiers. They tried to inseminate women with monkey sperm and impregnate female chimpanzees with human sperm. All of the attempts failed. But now we have genetic control over the donors and recipients, which is why they might be harvesting rare O-negative blood via transfusion, to reduce the chances of immuno-shock in the impregnated female if the source species carried the same blood.”

“Why is that type of blood so rare?” Tyrell asked.

“Evolution,” the doctor said. “Most blood groups can be traced back to our evolutionary cousins via proteins, and human blood reacts with the blood of rhesus monkeys as a result of our shared antibodies. Some ninety percent of people have the rhesus antibody in their blood, hence our shared common origin.”

“But some don’t,” Tyrell said.

“About ten percent of people have rhesus-negative blood, which means that the antibodies are not present. That’s good for other people as they can receive the blood from O-negative donors without fear of rejection. The problem is its heritage: O-negative blood constitutes less than seven percent of the world population. We just don’t know where the hell it comes from, as it’s the purest form of human blood and the only type that cannot be cloned. Most believe that it’s something like our original human blood before the mixing of populations, but nobody’s really sure.”

Tyrell tried to understand what the doctor was saying.

“So this blood type has no apparent origin in human evolution?”

“It evolved all right, it’s just that we can’t tell how or where it started. Our species evolved in Africa, yet only one percent of rhesus-negative people are of African descent. That means it must have appeared after our dispersal from Africa millions of years ago. The highest concentration of people with rhesus-negative blood live in the Basque region and Israel.”

“When did it appear?” Lopez asked curiously.

“Our best estimate is around five to six thousand years ago, roughly the time that human civilization began.”

“The dawn of recorded history,” Lopez said. “Didn’t Claretta mention something about that, something she’d heard from Daniel?”

Tyrell nodded.

“Men of renown,” he murmured. “Some kind of quote. And our pastor at the Evangelical Alliance has been running blood-donation charities across the District.”

Tyrell thanked Dr. Holloway before turning and walking away with Lopez, who produced her notebook.

“I want you to get me a list of every surgeon who has ever served in the District, Virginia, New Jersey, and Maryland. Start with people who have worked for the Evangelical Alliance’s hospitals.”

Lopez nodded, scribbling as she did so.

“Then get me everything you can on the American Evangelical Alliance’s activities over the last ten years, specifically those that involve drug rehabilitation and blood work. Make sure that you learn everything you can about Kelvin Patterson: how he works, where he works, who supports him, who hates him, and why.”

“Wait one,” Lopez looked at Tyrell. “You can’t just build a case here and then get in his face. It might send a warning to whoever is responsible.”

“I don’t give a damn if he turns out to be God’s right-hand man and can turn shit into gold just by looking at it. If he’s the owner of this hospital, then he’s got some responsibility for it, and if he’s innocent of any crime, then he should have no problems assisting us.”

Lopez sighed, brushing a thick lock of black hair from her eyes. “Run any of this by the district attorney and I’ll be impressed.”